ULTRASONIC MEASURMENT OF MIDDLE EAR FLUID VISCOSITY
中耳液体粘度的超声波测量
基本信息
- 批准号:6349641
- 负责人:
- 金额:$ 8.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-15 至 2001-09-14
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This program will develop innovative noninvasive methodology employing ultrasound to measure middle ear fluid viscosity to better identify children at risk for bacterial (purulent) acute otitis media (AOM) as well as children at high risk for "glue ear" (mucoid) likely to require surgical intervention. The technology will go beyond near-routine detection of middle ear fluid to a determination of the quality of the fluid. This will have significant impact on the approach to middle ear disease in children as it will support differentiation of bacterial from non-bacterial or mucoid otitis and provide an additional tool to differentiate children likely to benefit from antimicrobial therapy. Also, identification of children with thick viscous fluid in the middle ear will permit early identification of those at highest risk for persistent effusion and conductive hearing loss. All acoustic excitation and measurements will be made through the tympanic membrane to minimize the invasiveness of the procedure making it suitable for a number of clinical settings. In Phase I, an experimental facility capturing the acoustic and fluid dynamic characteristics of the middle ear will be built and the feasibility of measuring viscosities demonstrated. A concept for a clinical device will be developed incorporating the findings. PROPOSED COMMERCIAL APPLICATIONS: This project will create a new class of measurement instruments to improve management of Otitis Media by providing information on the nature of middle ear fluids that cannot now be obtained. As acute Otitis Media is the most common diagnosis made by healthcare professionals caring for children and the most frequent reason for the administration of prescription drugs for children under 2 years old, there should be a substantial clinical market for these instruments. In addition, devices for home use may also be practical. This would create a larger market. Instruments of the type to be developed may also find other medical and nonmedical applications where noninvasive characterization of fluids is required.
该计划将开发创新的非侵入性方法,采用超声测量中耳液粘度,以更好地识别有细菌性(化脓性)急性中耳炎(AOM)风险的儿童以及可能需要手术干预的“胶耳”(粘液)高风险儿童。该技术将超越中耳液的常规检测,以确定液体的质量。这将对儿童中耳疾病的治疗方法产生重大影响,因为它将支持区分细菌性和非细菌性或粘液性中耳炎,并提供一种额外的工具来区分可能受益于抗菌治疗的儿童。此外,识别中耳有粘稠液体的儿童将允许早期识别持续性积液和传导性听力损失的最高风险。所有声激励和测量将通过鼓膜进行,以最大限度地减少手术的侵入性,使其适用于许多临床环境。在第一阶段,将建立一个实验设施,捕捉中耳的声学和流体动力学特性,并证明测量粘度的可行性。将结合研究结果开发临床器械的概念。拟议的商业应用:该项目将创建一种新的测量仪器,通过提供有关目前无法获得的中耳液性质的信息来改善中耳炎的管理。由于急性中耳炎是护理儿童的医疗保健专业人员最常见的诊断,也是2岁以下儿童处方药给药的最常见原因,因此这些仪器应该有很大的临床市场。此外,家用设备也可能是实用的。这将创造更大的市场。待开发的类型的仪器还可以找到需要流体的非侵入性表征的其他医疗和非医疗应用。
项目成果
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