DYNAMIC ENHANCEMENT OF DIALYSIS EFFICIENCY

动态提高透析效率

• 批准号: 2867587
• 负责人: Steven Allen Africk
• 金额: $ 9.77万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867587
• 关键词: artificial membranes; biomedical equipment development; clearance rate; creatinine; dialysis; diffusion; membrane activity; sound; sound frequency; vibration; vitamin B12

Dialysis is an effective but time consuming procedure. The project will seek to produce a dialysis acceleration device which will increase dialysis efficiency. This could allow for a reduction of dialysis duration and for more effective dialysis for patients who made need more clearance. The mechanism to be employed is to increase molecular diffusion rates through dialysis membranes by application of acoustic and/or vibrational energy at the filter surface. The approach will be to define an excitation device which can be used as an adjunct to existing dialysis hardware, requiring very little modification to dialysis machines or filters, or none if possible. The result will be a stand alone product for use with existing dialysis machines and standard or very slightly modified dialyzers. Three basic types of dynamic excitation will be evaluated over frequencies ranging from tens of hertz to ultrasonic. Laboratory excitation device(s) will be fabricated and their ability to increase, for example, shear rates at the filtration surfaces will be measured.. The effectiveness of thes3e excitations to enhance dialysis efficiency will be determined by measurement of clearance rates for creatine and B-12 in a saline solution using standard dialysis equipment. PROPOSED COMMERCIAL APPLICATION: This technology could reduce the time necessary for dialysis and potentially save thousands of man hours for physicians, nurses, technicians, and patients, with enormous economic impact. The dynamic dialysis accelerator device will be a stand alone product which could be purchased separately from and used with standard dialysis machines, making the potential market several hundred thousand worldwide. If disposable parts are necessary the market would be larger.

透析是一种有效但耗时的程序。 该项目将寻求生产一种透析加速装置，以提高透析效率。 这可以缩短透析持续时间，并为需要更多清除的患者提供更有效的透析。 所采用的机制是通过在过滤器表面施加声能和/或振动能来增加通过透析膜的分子扩散速率。 该方法将定义一种激励装置，该装置可用作现有透析硬件的附件，只需对透析机或过滤器进行很少的修改，或在可能的情况下不进行修改。 其结果将是一个独立的产品，可与现有的透析机和标准或稍微修改的透析器一起使用。将在从几十赫兹到超声波的频率范围内评估三种基本类型的动态激励。 将制造实验室激发装置，并测量其增加过滤表面剪切速率的能力。 这些激发提高透析效率的有效性将通过使用标准透析设备测量盐水溶液中肌酸和B-12的清除率来确定。拟定商业应用：这项技术可以减少透析所需的时间，并可能为医生、护士、技术人员和患者节省数千个工时，带来巨大的经济影响。 动态透析加速器设备将是一个独立的产品，可以单独购买，并与标准透析机一起使用，使全球潜在市场达到数十万。 如果一次性部件是必要的，市场将更大。