APPARATUS FOR THE PREVENTION OF CATHETER INFECTIONS

预防导管感染的装置

• 批准号: 6073614
• 负责人: ADRIAN J DENVIR
• 金额: $ 10.52万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2000-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6073614
• 关键词: antiseptic sterilization; biomedical equipment development; catheterization; chemical synthesis; disease /disorder prevention /control; drug delivery systems; electrochemistry; infection; medical complication; miniature biomedical equipment; ozone

In the United States each year 20 million hospital patients are catheterized. Catheter related infections are associated with increased morbidity, mortality rates of between 10% and 20%, prolonged hospitalization, and increased medical costs of thousands of dollars per patient. The skin of a catheterized patient is the most common source for the microorganisms that are associated with catheter infections. Lynntech Inc has developed a revolutionary method of making miniaturized ozone generators that can be used to supply a measured dose of ozone gas to a specific area of skin in a safe and controlled manner. The unit, containing the micro ozone generator, fluid management system, power supply, and necessary electronics, will have dimensions no larger than a wrist watch, and cost less than $5. During the Phase I research, we will develop and build a fully contained ozonation unit for bench scale testing. The Phase I feasibility study will demonstrate that the unit can be used to successfully prevent bacteria migration and prevent catheter contamination. Extended testing will show the long term benefits of the system when compared to other treatments such as antibiotic bonded catheters, silver coated catheters, and silver-sulfadiazine solution. PROPOSED COMMERCIAL APPLICATIONS: It is the many applications of this technology that make it so attractive. This technology is not just applicable to catheter infection prevention. There are many areas of infection prevention such as burn wound treatment and plastic surgery that would benefit greatly from this product.

在美国，每年有2000万住院患者接受导管插入术。导管相关感染与发病率增加、10%至20%的死亡率、住院时间延长以及每位患者数千美元的医疗费用增加相关。导管插入患者的皮肤是与导管感染相关的微生物的最常见来源。Lynntech公司开发了一种革命性的方法，使微型臭氧发生器，可用于提供测量剂量的臭氧气体，以一种安全和可控的方式到皮肤的特定区域。该装置包含微型臭氧发生器、流体管理系统、电源和必要的电子设备，尺寸不超过手表，成本不到5美元。在第一阶段的研究中，我们将开发和建造一个完整的臭氧化装置进行实验室规模的测试。I期可行性研究将证明该装置可用于成功防止细菌迁移和防止导管污染。与其他治疗（如抗生素粘合导管、银涂层导管和磺胺嘧啶银溶液）相比，扩展试验将显示该系统的长期受益。建议的商业应用：正是这项技术的许多应用使它如此具有吸引力。这项技术不仅适用于预防导管感染。有许多感染预防领域，如烧伤伤口治疗和整形外科，将大大受益于这种产品。