New Point of Care System for Burn Wound Treatment

描述（由申请人提供）：在美国，每年有200万人遭受烧伤，导致大约10万至30万人住院。在这200万人中，超过1.2万人最终将死于烧伤相关感染。遭受烧伤的人失去了一部分皮肤，削弱了身体抵御细菌感染的主要屏障之一。此外，烧伤痂中的坏死组织与血清蛋白的存在相结合，为微生物提供了丰富的培养基。除了外皮的丧失外，热损伤还会对局部和全身免疫产生不利影响。由于这些原因，感染和败血症是住院烧伤患者最常见的死亡原因。然而，新的烧伤创面管理方法需要混合使用抗菌剂和抗生素来对抗感染；由于微生物的耐药菌株，它们的效果越来越差。在这个第一阶段的努力，我们将证明一个根本的新方法的可行性烧伤创面护理。护理点（POC）系统将被设计为产生无菌盐水或水，以湿润或润湿疤痕和切除后移植的敷料，并提供广泛的抗菌药物，有效对抗革兰氏阳性和革兰氏阴性细菌和真菌到伤口表面。

DESCRIPTION (provided by applicant): Each year in the United States, two million people suffer burn injuries resulting in approximately 100,000 - 300,000 hospitalizations. Of these two million, more than 12,000 will eventually die of burn-related infections. People suffering from burn wounds have lost a portion of their integument, diminishing one of the body's main defenses against bacterial infection. In addition, the necrotic tissue in the burn eschar, combined with the presence of serum proteins, provides a rich culture medium for microorganisms. Added to the loss of integument is the adverse affect of thermal injury on both local and systemic immunity. For these reasons, infections and sepsis are the most common cause of death among hospitalized burn patient. New methods of burn wound management require a cocktail of antimicrobial and antibiotic agents to fight infection however; they are becoming less effective due to resistant strains of microorganisms. In this Phase I effort we will demonstrate the feasibility of a fundamentally new method for burn wound care. The point of care (POC) system will be designed to generate sterile saline or water to moisten or wet the dressings for both the eschar as well as the graft after excision and deliver a broad based antimicrobial agent effective, against gram positive and gram-negative bacteria and fungi to the wound surface.