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NOVEL METHOD FOR DETECTING NON-HODGKIN'S LYMPHOMA

NOVEL METHOD FOR DETECTING NON-HODGKIN'S LYMPHOMA
检测非霍奇金淋巴瘤的新方法
批准号:
6130918
负责人:
PHILLIP T MOEN
金额:
$23.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-03-07 至 2001-02-28

项目摘要

项目成果

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中文摘要
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英文摘要
B-cell non-Hodgkin's lymphoma (NHL) is the fifth most common cancer in this country with rapidly increasing incidence rates worldwide. Approximately 60% of NHL's are characterized by the t(14;18)(q32;q21) chromosomal translocation. These tumors are treated by chemotherapy and bone marrow transplantation; however, many patients relapse and become refractory to treatment. Diagnosis and post-treatment follow-up are currently performed by either karyotype analysis, Southern blotting, or polymerase chain reaction (PCR). Problems with specificity, sensitivity and low throughput, however, underscore the need for a precise, reliable, rapid method to detect tumor cells, especially in the post-treatment set up. Fluorescence in situ hybridization (FISH) has emerged as a promising method for detecting cancer cells. However, conventional FISH is a manual, labor intensive operation, making detection of cancer cells, which are typically present in low frequencies in patient samples, difficult. PROPOSED COMMERCIAL APPLICATIONS: The proposed assay will provide a rapid, sensitive, and accurate method for monitoring remission and therapy for a significant number of B-Cell Lymphoma patients. The estimated annual revenue potential is $183M.
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