BENEFITS OF EXERCISE IN ELDERLY CONGESTIVE HEART FAILURE PATIENTS

运动对老年充血性心力衰竭患者的好处

• 批准号: 6281966
• 负责人: PETER V VAITKEVICIUS
• 金额: $ 5.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281966
• 关键词: aerobic exercise; clinical research; congestive heart failure; echocardiography; heart function; heart imaging /visualization /scanning; human data; human old age (65+); human therapy evaluation; muscle strength; statistics /biometry; vascular resistance

Exercise Testing & Training Facility utilization only. Chronic congestive heart failure (CHF) secondary to a reduction in left ventricular systolic function is extremely common in the elderly and contributes to a substantial decline in functional capacity. Many clinicians limit the physical activity of older patients with heart failure due to a fear of precipitating myocardial ischemia, worsening the symptoms of CHF, or eliciting serious dysrhythmias, thus promoting deconditioning and functional limitations. Younger CHF patients can derive substantial benefits from a regular aerobic exercise training. The effectiveness of aerobic and resistive training to increase the functional independence of old patients with CHF has not been addressed. It is our hypothesis that symptom-limited aerobic and resistive exercise training can be safely performed in the elderly. This prospective, randomized trial will characterize the functional limitations of older New York Heart Association (NYHA) class II and III heart failure patients and determine if a combined protocol of aerobic/resistive exercise is more effective than aerobic training alone in improving physical activity and maximal aerobic capacity. These aims will be assessed by a direct comparison of the aerobic and combined aerobic/resistive training protocols to age- matched controls receiving usual care in a randomized, prospective study design. The effects of exercise training on the mechanisms that may be responsible for the benefits will be carefully assessed including: 1) muscle strength, b) arterial compliance, 3) alteration in left ventricular function as assessed by 2D echocardiography and MUGA scan.

仅限运动测试和训练设施的使用。 左心功能下降继发慢性充血性心力衰竭(CHF) 心脏收缩功能在老年人和老年人中非常常见 导致功能能力大幅下降。许多 临床医生限制老年心脏病患者的体力活动 由于担心引发心肌缺血而导致的衰竭，使病情恶化 心力衰竭的症状，或引发严重的心律失常，从而促进 解除条件和功能限制。年轻的CHF患者可以 从定期的有氧运动训练中获得实质性的好处。这个 有氧和耐力训练对提高人体机能的有效性 老年充血性心力衰竭患者的独立性尚未得到解决。这是我们的 症状受限有氧和耐力运动训练假说 可以安全地在老年人身上执行。这项前瞻性随机试验 将表征较老的纽约心脏的功能局限性 美国心脏协会(NYHA)II级和III级心力衰竭患者并确定 如果有氧/耐力运动的组合方案更有效 比单纯的有氧训练在改善体力活动和最大 有氧能力。这些目标将通过以下直接比较来评估 针对年龄的有氧和组合有氧/耐力训练方案- 随机前瞻性研究中接受常规护理的配对对照组 设计。运动训练对可能存在的机制的影响 负责福利的人将被仔细评估，包括：1) 肌力，b)动脉顺应性，3)左心室改变 通过二维超声心动图和MUGA扫描评估其功能。