GLP-1 EFFECT ON GLUCOSE UPTAKE AND HEPATIC GLUCOSE OUTPUT

关于胰升糖素样肽(GLP-1)是否具有 GLP-1对外周葡萄糖摄取的影响 Se(即，与其胰岛素营养作用分开)。此外，还有 可能是GLP-1和GLP-1酰胺之间的器官特异性差异效应。 这项研究的目的是首先检查GLP-1感染的影响 正常血糖维持期间对肝脏葡萄糖摄取和肝脏的影响 葡萄糖产量(HGP)。在第二项研究中，将在 在第一次研究后至少几周，志愿者将收到一份 以一种导致血浆胰岛素谱的方式输入胰岛素 与输注GLP-1诱导的结果几乎相同。如果GLP-1做到了 确实有胰岛素样效应与高胰岛素血症分开 关于葡萄糖代谢(M)，那么M在第一个研究中应该是 在第二个研究中大于M。如果这是真的，那么第三项研究 将在增加胰岛素剂量的情况下进行，以便 产生的葡萄糖利用率等同于第一个 学习。这将量化GLP-1的S胰岛素样作用的程度 关于葡萄糖摄取本身。如果M在研究1之间没有不同 和2使用GLP-1，GLP-1将被输注以测试器官- 在肝脏和肌肉床上存在特定受体的差异。 已经证明，胰岛素营养之间没有差异。 人体内的这两种多肽。然而，无论是还是 NOT GLP-1对大鼠的葡萄糖摄取和分泌有任何胰岛素样作用 肌肉和肝脏。

There is controversy over whether glucagon-like peptide (GLP-1) has effects on peripheral glucose uptake which can be attributed to GLP-1 per se (i.e., separate from its insulinotrophic effects). Furthermore, there may be an organ specific differential effect between GLP-1 and GLP-1amide. The aim of this study is to first examine the effect of GLP-1 influsion during a period of maintained euglycemia on glucose uptake and hepatic glucose production (HGP). In the second study, which will be repeated at least htree weeks after the first study, volunteers will receive an influsion of insulin in a manner which results in plasma insulin profile nearly identical to those induced by the infusion of GLP-1. If GLP-1 does indeed have insulin-like effects separate from hyperinsulinemia with respect to glucose metabolized (M), then M in the first study should be greater than M in the second study. If this is true, then a third study will be performed where the insulin dose will be increased in order to produce an equivalent glucose utilization to that obtained in the first study. This will quantify the extent of GLP-1's insulin-like effect with respect to glucose uptake per se. If M is not different between study 1 and 2 with the use of GLP-1, GLP-1 will be infused to test whether organ- specific receptor differences are present in the liver and the muscle bed. It has been shown that there are no insulinotrophic differences between these two peptides in humans. However, there is controversy whether or not GLP-1 has any insulin-like effects on glucose uptake and production in the muscle and liver.