Elucidating the mechanism behind oscillation between glycolysis and gluconeogenesis

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Project Summary Metabolism is a dynamic network of biochemical reactions capable of adapting to changing environments. In changing glucose availability, glycolysis and gluconeogenesis support systemic glucose homeostasis. In the parent award, we investigate the regulation and coordination of glycolysis and gluconeogenesis in mammalian cells under dynamic nutrient environments. The goal of this supplement application is to acquire funding to support one talented and motivated undergraduate student researcher for 10 weeks in the summer of 2023. She will measure the rates of glycolysis and gluconeogenesis in mammalian cells under dynamic nutrient environments by employing biochemical assays and mass spectrometry. She will be mentored by the PI and one PhD student who will train her to perform cell culture experiments, metabolic measurements, and analyze results. She will join the Bruins-In-Genomics (BIG) Summer Program on UCLA campus to broaden her scientific horizons and develop professional skills. She will share her research outcomes with the PI’s research group and other researchers on campus by presenting her project at the 2023 BIG Research Symposium. These activities will further the undergraduate student researcher’s passion for biomedical science and act as a steppingstone for her to become a future STEM leader.