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ARGININE AMINOPEPTIDASES OF CRYPTOSPORIDIUM PARVUM

ARGININE AMINOPEPTIDASES OF CRYPTOSPORIDIUM PARVUM
小隐孢子虫的精氨酸氨基肽酶
批准号:
6281668
负责人:
Pablo C Okhuysen
金额:
$1.36万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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中文摘要
翻译
蛋白酶在微小隐孢子虫存活、附着和繁殖中的作用 入侵是未知的。 在这项MCAP研究的资助期间, 对C.小氨肽酶完成。 一 确定了在寄生虫脱囊中的特定作用, 发现抑制性化合物在防止氨基- 肽酶介导的脱囊。此外,基础生化 表征,从基因组DNA获得部分序列 图书馆努力获得完整的序列和蛋白表达 将继续研究C. parvum 氨基肽酶
英文摘要
The role of proteases in Cryptosporidium parvum survival, attachment, and invasion are unknown. During the funded period of this MCAP study, further characterization of C. parvum aminopeptidase was accomplished. A specific role in parasitic excystation was identified and several inhibitory compounds were found to be effective in preventing amino- peptidase mediated excystation. In addition, basic biochemical characterization, a partial sequence was obtained from a genomic DNA library. Efforts to obtain the complete sequence and protein expression will continue to investigate the immunoreactivity of C. parvum aminopeptidase.
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Mucosal determinants of Cryptosporidium infection
  • 批准号:
    10396594
  • 项目类别:
  • 资助金额:
    $55.71万
  • 财政年份:
    2019
  • 负责人:
    Pablo C Okhuysen
  • 依托单位:
Mucosal determinants of Cryptosporidium infection
  • 批准号:
    10160782
  • 项目类别:
  • 资助金额:
    $44.01万
  • 财政年份:
    2019
  • 负责人:
    Pablo C Okhuysen
  • 依托单位:
Mucosal determinants of Cryptosporidium infection
  • 批准号:
    10601135
  • 项目类别:
  • 资助金额:
    $55.71万
  • 财政年份:
    2019
  • 负责人:
    Pablo C Okhuysen
  • 依托单位:
IL-2 (PROLEUKIN) IN HIV+ PATIENTS IN A RANDOMIZED INTERNATIONAL TRIAL (ESPRIT)
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