Studies on the complex interaction of autophagy with endoplamic reticulum aminopeptidase 1, unfolded protein response and natural killer cell response in the pathogenesis of ankylosing spondylitis
强直性脊柱炎发病机制中自噬与内质网氨肽酶1、未折叠蛋白反应和自然杀伤细胞反应复杂相互作用的研究
基本信息
- 批准号:310329
- 负责人:
- 金额:$ 7.29万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-03-01 至 2015-03-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Ankylosing spondylitis (AS) is the most severe and commonest inflammatory joint disease affecting the spine. The gene HLA-B27 is strongly associated with AS. A newly identified genetic association of AS with Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
强直性脊柱炎(AS)是影响脊柱的最严重和最常见的炎性关节疾病。HLA-B27基因与AS密切相关。一种新发现的AS与内质网氨肽酶1(ERAP 1)的遗传关联
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Haroon Nigil其他文献
Haroon Nigil的其他文献
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{{ truncateString('Haroon Nigil', 18)}}的其他基金
HIF1-alpha interacts with MIF to drive inflammation and new bone formation in spondyloarthritis
HIF1-α 与 MIF 相互作用,促进脊柱关节炎中的炎症和新骨形成
- 批准号:
445586 - 财政年份:2021
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Therapeutic Targeting of MIF in a Spondyloarthritis Mouse Model
MIF 在脊柱关节炎小鼠模型中的治疗靶向
- 批准号:
381460 - 财政年份:2018
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Human Immunology Spondyloarthritis Team (HUMISPOT) studying immunopathogenesis, disease heterogeneity and drug discovery in spondyloarthritis
人类免疫学脊柱关节炎团队 (HUMISPOT) 研究脊柱关节炎的免疫发病机制、疾病异质性和药物发现
- 批准号:
395724 - 财政年份:2018
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Personalized medicine for ankylosing spondylitis
强直性脊柱炎个体化用药
- 批准号:
365355 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Definitive treatment of AS by blocking Macrophage Migration Inhibitory Factor (MIF)
通过阻断巨噬细胞迁移抑制因子 (MIF) 彻底治疗 AS
- 批准号:
351879 - 财政年份:2016
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Immunogenetic influences on the clinical phenotype of Ankylosing Spondylitis
免疫遗传学对强直性脊柱炎临床表型的影响
- 批准号:
194035 - 财政年份:2009
- 资助金额:
$ 7.29万 - 项目类别:
Fellowship Programs
Immunogenetic influences on the clinical phenotype of ankylosing spondylitis
免疫遗传学对强直性脊柱炎临床表型的影响
- 批准号:
197231 - 财政年份:2009
- 资助金额:
$ 7.29万 - 项目类别:
Studentship Programs
相似国自然基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
- 批准号:31171277
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data
- 批准号:31070748
- 批准年份:2010
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Tissue tropism of PD-1 therapy in ulcerative colitis and rheumatoid arthritis
PD-1治疗溃疡性结肠炎和类风湿性关节炎的组织向性
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Do autoantibodies to aberrantly glycosylated MUC1 drive extra-articular rheumatoid arthritis, and can GSK assets prevent driver antigen formation?
针对异常糖基化 MUC1 的自身抗体是否会导致关节外类风湿性关节炎,GSK 资产能否阻止驱动抗原形成?
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MR/Y022947/1 - 财政年份:2024
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$ 7.29万 - 项目类别:
Research Grant
Preclinical development of an extracellular vesicle biotherapeutic for juvenile idiopathic arthritis
幼年特发性关节炎细胞外囊泡生物治疗药物的临床前开发
- 批准号:
10068495 - 财政年份:2024
- 资助金额:
$ 7.29万 - 项目类别:
Collaborative R&D
The delivery of miR-9 and RasGRP4 siRNA via high selectivity bispecific antibody conjugated lactosome: Targeting therapy for rheumatoid arthritis (RA) active synovial macrophage and osteoclast
通过高选择性双特异性抗体缀合乳糖体递送 miR-9 和 RasGRP4 siRNA:类风湿性关节炎 (RA) 活性滑膜巨噬细胞和破骨细胞的靶向治疗
- 批准号:
24K19237 - 财政年份:2024
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$ 7.29万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Exploring the inflammatory mediators degraded by MMP-2 in MMP-2-deficient mice with knee arthritis through a novel TMT-TAILS quantitative proteomics
通过新型 TMT-TAILS 定量蛋白质组学探索 MMP-2 缺陷型膝关节炎小鼠中 MMP-2 降解的炎症介质
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24K19850 - 财政年份:2024
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Grant-in-Aid for Early-Career Scientists
Development of an adaptive platform trial to prevent Rheumatoid Arthritis in partnership with First Nations People.
与原住民合作开发预防类风湿关节炎的适应性平台试验。
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491810 - 财政年份:2023
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The role of diet, as mediated by the gut microbiome, on childhood arthritis disease activity: a feasibility intervention study.
肠道微生物组介导的饮食对儿童关节炎疾病活动的作用:一项可行性干预研究。
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489316 - 财政年份:2023
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研究缺氧诱导因子-1 (HIF-1) 作为幼年特发性关节炎的新治疗靶点。
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23K14987 - 财政年份:2023
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DEMORA: DEep spatial characterization of synovial MacrOphages in Rheumatoid Arthritis
DEMORA:类风湿性关节炎滑膜巨噬细胞的深度空间特征
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