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Studies on the complex interaction of autophagy with endoplamic reticulum aminopeptidase 1, unfolded protein response and natural killer cell response in the pathogenesis of ankylosing spondylitis

Studies on the complex interaction of autophagy with endoplamic reticulum aminopeptidase 1, unfolded protein response and natural killer cell response in the pathogenesis of ankylosing spondylitis
强直性脊柱炎发病机制中自噬与内质网氨肽酶1、未折叠蛋白反应和自然杀伤细胞反应复杂相互作用的研究
批准号:
310329
负责人:
Haroon Nigil
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-03-01 至 2015-03-01

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中文摘要
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英文摘要
Ankylosing spondylitis (AS) is the most severe and commonest inflammatory joint disease affecting the spine. The gene HLA-B27 is strongly associated with AS. A newly identified genetic association of AS with Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
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会议论文
HIF1-alpha interacts with MIF to drive inflammation and new bone formation in spondyloarthritis
  • 批准号:
    445586
  • 项目类别:
    Operating Grants
  • 资助金额:
    $48.49万
  • 财政年份:
    2021
  • 负责人:
    Haroon Nigil
  • 依托单位:
Therapeutic Targeting of MIF in a Spondyloarthritis Mouse Model
  • 批准号:
    381460
  • 项目类别:
    Operating Grants
  • 资助金额:
    $22.01万
  • 财政年份:
    2018
  • 负责人:
    Haroon Nigil
  • 依托单位:
Human Immunology Spondyloarthritis Team (HUMISPOT) studying immunopathogenesis, disease heterogeneity and drug discovery in spondyloarthritis
  • 批准号:
    395724
  • 项目类别:
    Operating Grants
  • 资助金额:
    $1.46万
  • 财政年份:
    2018
  • 负责人:
    Haroon Nigil
  • 依托单位:
Personalized medicine for ankylosing spondylitis
  • 批准号:
    365355
  • 项目类别:
    Operating Grants
  • 资助金额:
    $14.57万
  • 财政年份:
    2017
  • 负责人:
    Haroon Nigil
  • 依托单位:
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data