DVT IN CHILDREN WITH ACUTE IMMOBILITY OR LOWER EXTREMITY PARALYSIS

急性行动不便或下肢瘫痪儿童的 DVT

• 批准号: 6282040
• 负责人: DEBORAH L MCLEISH
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282040
• 关键词: cardiovascular disorder epidemiology; child (0-11); clinical research; disease /disorder proneness /risk; human subject; immobilization of body part; limb movement; paralysis; venous thrombosis

Children with acute immobility (whether by neurological or chemical paralysis, or for conditions related to medical or surgical status) are at increased risk for the development of deep venous thromboses (DVTs). Certain variables may increase this risk including history of previous DVT, hypercoagulability disorder, or trauma. Instrumentation such as central or femoral venous catheterization can increase this risk further. Pulmonary embolus has also been reported in children who have developed DVTs, so there is the potential for significant morbidity. Post phlebiotic syndrome is also a potential cause for morbidity, though it has been reported only occasionally in children. Since there are prophylactic measures for DVTs, an estimation of the prevalence is important to compare the costs and benefits of prophylactic measures and medications. Very few studies have been performed to document DVTs in children, yet most medical practitioners working with these groups of children have had clinical experience with DVTs in the pediatric age group. The purpose of this study is to determine the prevalence of deep venous thromboses in children who are admitted to the UW Children's Hospital Pediatric Intensive Care Unit and the hospital's Burn Unit, and who are either paralyzed (neurological or chemical paralysis); immobilized because of casting or traction devices; or who are at bed rest for medical or surgical conditions. The long term goal of this research project is formulate a future study to examine the efficacy of DVT prophylaxis in this patient population.

儿童急性不能动(无论是神经性或化学性的 瘫痪，或与内科或手术状态有关的情况) 发生深静脉血栓(DVT)的风险增加。 某些变量可能会增加这种风险，包括以前的 深静脉血栓、高凝障碍或创伤。工具，如 中心静脉或股静脉插管会增加这种风险。 再远一点。据报道，患有肺血栓的儿童也出现了肺血栓。 发生了深静脉血栓，因此有可能出现严重的发病率。 然而，静脉炎后综合征也是发病的一个潜在原因。 只有在儿童中偶尔会出现这种情况。 由于对深静脉血栓有预防措施，估计 流行率是比较成本和收益的重要因素。 预防措施和药物。很少有研究是 为记录儿童深静脉血栓形成而进行的手术，但大多数医生 与这些儿童一起工作有过临床经验 儿童年龄组的深静脉血栓形成。 这项研究的目的是确定深静脉的患病率。 华盛顿大学儿童医院住院儿童的血栓形成 儿科重症监护病房和医院的烧伤病房，谁是 瘫痪的(神经性或化学性瘫痪)；瘫痪的 因铸造或牵引装置；或因以下原因卧床休息 内科或外科疾病。 这项研究项目的长期目标是制定一项未来的研究 目的：研究在这一人群中预防深静脉血栓形成的效果。