DVT IN CHILDREN WITH ACUTE IMMOBILITY OR LOWER EXTREMITY PARALYSIS

急性行动不便或下肢瘫痪儿童的 DVT

• 批准号: 6121668
• 负责人: DEBORAH L MCLEISH
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121668
• 关键词: cardiovascular disorder epidemiology; child (0-11); clinical research; disease /disorder proneness /risk; human subject; immobilization of body part; limb movement; paralysis; venous thrombosis

Children with acute immobility (whether by neurological or chemical paralysis, or for conditions related to medical or surgical status) are at increased risk for the development of deep venous thromboses (DVTs). Certain variables may increase this risk including history of previous DVT, hypercoagulability disorder, or trauma. Instrumentation such as central or femoral venous catheterization can increase this risk further. Pulmonary embolus has also been reported in children who have developed DVTs, so there is the potential for significant morbidity. Post phlebiotic syndrome is also a potential cause for morbidity, though it has been reported only occasionally in children. Since there are prophylactic measures for DVTs, an estimation of the prevalence is important to compare the costs and benefits of prophylactic measures and medications. Very few studies have been performed to document DVTs in children, yet most medical practitioners working with these groups of children have had clinical experience with DVTs in the pediatric age group. The purpose of this study is to determine the prevalence of deep venous thromboses in children who are admitted to the UW Children's Hospital Pediatric Intensive Care Unit and the hospital's Burn Unit, and who are either paralyzed (neurological or chemical paralysis); immobilized because of casting or traction devices; or who are at bed rest for medical or surgical conditions. The long term goal of this research project is formulate a future study to examine the efficacy of DVT prophylaxis in this patient population.

急性不动的儿童（无论是神经性或化学性麻痹，还是与医疗或手术状态相关的疾病）发生深静脉血栓（DVT）的风险增加。 某些变量可能会增加这种风险，包括既往DVT史、高凝障碍或创伤。 中心静脉或股静脉导管插入术等器械会进一步增加这种风险。 肺栓塞也曾在患有DVT的儿童中报告，因此有可能发生严重的发病率。 静脉注射后综合征也是发病的一个潜在原因，尽管仅偶尔在儿童中报告。由于存在DVT的预防措施，因此对患病率的估计对于比较预防措施和药物治疗的成本和收益非常重要。 很少有研究记录了儿童DVT，但大多数与这些儿童群体一起工作的医生都有儿科年龄组DVT的临床经验。本研究的目的是确定深静脉血栓的患病率在儿童谁是承认的UW儿童医院儿科重症监护病房和医院的烧伤病房，谁是瘫痪（神经或化学麻痹）;固定，因为铸造或牵引设备;或谁是在床上休息的医疗或手术条件。本研究项目的长期目标是制定一项未来研究，以检查DVT预防在该患者人群中的疗效。