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SAFETY OF TIZANIDINE IN PATIENTS WITH MS--OPEN LABEL EVALUATION

SAFETY OF TIZANIDINE IN PATIENTS WITH MS--OPEN LABEL EVALUATION
替扎尼定对多发性硬化症患者的安全性——开放标签评估
批准号：
6281660
负责人：
Jerry Saul Wolinsky
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281660
关键词：
alpha adrenergic agent anticholinergic agent clinical research clinical trials dosage drug screening /evaluation human subject human therapy evaluation longitudinal human study multiple sclerosis muscle relaxants nervous system disorder chemotherapy oral administration placebos

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中文摘要
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英文摘要
This multicenter, open-label long-term study is a followup to the placebo- controlled study to determine a) the safety and b) the efficacy of oral tizanidine in reducing excessive muscle tone associated with spasticity in patients with multiple sclerosis. This study will determine the safety of long-term treatment with tizanidine at maximally tolerated dosage of up to 12 mg three times a day. This study was completed with FDA approval of tizanidine with an indication for use for treatment of spasticity associated with multiple sclerosis.
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