DIABETES TYPE 1 PREVENTION TRIAL

为了确定在非肿瘤患者中通过基于抗原的治疗进行早期干预是否有效， 胰岛素依赖型糖尿病患者的糖尿病亲属可以延迟他们的发展， 胰岛素依赖型糖尿病是一种临床疾病。 本研究的其他目标包括：1） 确定这些干预措施对β细胞功能的影响; 2） 以确定这些干预措施对体液和细胞的影响， 针对胰腺β细胞及其抗原的免疫应答; 3） 以提高亲属中IDDM的可预测性; 4）确定 影响疾病进展。

To determine whether early intervention by antigen based therapies in non- diabetic relatives of persons with IDDM can delay their development of IDDM as a clinical disease. Other aims in this study will include 1) to determine the influence of these interventions of beta cell function; 2) to determine the influence of these interventions on humoral and cellular immune responses directed at pancreatic beta cells and their antigens; 3) to improve predicability of IDDM among relatives; 4) identify factors that influence disease progression.