DIABETES TYPE 1 PREVENTION TRIAL

1 型糖尿病预防试验

• 批准号: 6281842
• 负责人: KATHRYN M THRAILKILL
• 金额: $ 3.06万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281842
• 关键词: clinical research; clinical trials; diabetes mellitus genetics; diabetes mellitus therapy; disease /disorder prevention /control; family genetics; human subject; immunotherapy; insulin dependent diabetes mellitus; pancreatic islet function; prediabetic state

To determine whether early intervention by antigen based therapies in non- diabetic relatives of persons with IDDM can delay their development of IDDM as a clinical disease. Other aims in this study will include 1) to determine the influence of these interventions of beta cell function; 2) to determine the influence of these interventions on humoral and cellular immune responses directed at pancreatic beta cells and their antigens; 3) to improve predicability of IDDM among relatives; 4) identify factors that influence disease progression.

确定是否可以通过基于抗原的疗法进行早期干预 IDDM 患者的糖尿病亲属可以延缓其发展 IDDM作为一种临床疾病。 本研究的其他目标包括 1) 确定这些干预措施对 β 细胞功能的影响； 2） 确定这些干预措施对体液和细胞的影响 针对胰腺β细胞及其抗原的免疫反应； 3） 提高亲属间 IDDM 的可预测性； 4）确定因素 影响疾病进展。