DIABETES TYPE 1 PREVENTION TRIAL

1 型糖尿病预防试验

• 批准号: 6121302
• 负责人: KATHRYN M THRAILKILL
• 金额: $ 2.65万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121302
• 关键词: clinical research; clinical trials; diabetes mellitus genetics; diabetes mellitus therapy; disease /disorder prevention /control; family genetics; human subject; immunotherapy; insulin dependent diabetes mellitus; pancreatic islet function; prediabetic state

To determine whether early intervention by antigen based therpaies in non-diabetic relatives of persons with IDDM can delay their development of IDDM as a clinical disease. Other aims in this study will include 1) to determine the influence of these interventions of beta cell function; 2) to determine the influence of these interventions on humoral and cellular immune responses directed at pancreatic beta cells and their antigens; 3)to improve predicability of IDDM amond relatives;4)identify factors that influence disease progression.

确定IDDM患者的非糖尿病亲属通过抗原治疗的早期干预是否可以延缓IDDM作为临床疾病的发展。本研究的其他目的包括：1)确定这些干预措施对细胞功能的影响；2)确定这些干预措施对针对胰腺β细胞及其抗原的体液和细胞免疫反应的影响；3)提高亲缘关系中IDDM的可预测性；4)确定影响疾病进展的因素。