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COMPARISON OF ANTIRETROVIRAL ACTIVITY OF 3 COMBINATION REGIMENS IN HIV+ PATIENTS

COMPARISON OF ANTIRETROVIRAL ACTIVITY OF 3 COMBINATION REGIMENS IN HIV+ PATIENTS
3 种联合治疗方案对 HIV 患者的抗逆转录病毒活性比较
批准号：
6281695
负责人：
PHILIP C JOHNSON
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281695
关键词：
AIDS therapy HIV infections antiAIDS agent clinical research combination chemotherapy drug screening /evaluation helper T lymphocyte human subject human therapy evaluation lamivudine reverse transcriptase inhibitors virus RNA zidovudine

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中文摘要
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英文摘要
The aim of the protocol is to compare the antiretroviral activity, both in magnitude and duration, as measured by HIV-RNA and CD4 counts as well as the safety profile of several therapies in HIV+ patients. It is a 24-week open label trial involving double and triple therapy with the drugs Indinavir, ZDV, lamivudine (3TC), and DMP 266. DMP 266 is a potent non- nucleoside reverse transcriptase inhibitor which, in vitro, inhibits HIV production from infected cells.
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