HUMAN SMALL INTESTINAL MOTILITY AND TRANSPORT--CORRELATIVE STUDIES

人类小肠运动与运输--相关研究

• 批准号: 6281705
• 负责人: JOSEPH H SELLIN
• 金额: $ 1.36万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281705
• 关键词: clinical research; electrical measurement; gastrointestinal absorption /transport; gastrointestinal epithelium; gastrointestinal motility /pressure; glucose transport; human subject; membrane potentials; prostaglandin analogs; secretion; small intestines

Clinically, the intestine integrates transport and motility functions to provide a coordinated response to a variety of challenges. The goals of this study are 1) to determine the relationship between intestinal epithelial transport and motility by measuring parameters simultaneously in normal volunteers, and 2) to determine the feasibility of cable analysis to measure electrical resistance, a surrogate for permeability, in the intestine. To accomplish this, the investigators designed a tube to measure small bowel motility (pressure) and transport. In nine volunteers enrolled, we have demonstrated the feasibility of these simultaneous measurements of motility and electrogenic transport. Increasing concentrations of glucose elicit an increasing potential difference signal. Motility patterns are consistent with the three phases of the migrating motor complex. Interestingly, direct installation of glucose into the jejunum does not cause reversion to a fed pattern. Because of cholinergic side effects in one patient, we have decided to stop using acetyl choline as a secretory stimulus and will now use prostaglandin analogues.

临床上，肠整合了运输和运动功能， 协调应对各种挑战。 的目标 本研究的目的是：1）确定肠 通过同时测量参数的上皮运输和运动 在正常志愿者中，2）确定电缆的可行性 分析测量电阻，渗透率的替代品， 在肠道里。 为了实现这一点，研究人员设计了一种管 测量小肠运动（压力）和运输。 在9名志愿者中，我们已经证明了这些方法的可行性。 运动性和产电转运的同时测量。 葡萄糖浓度的增加会引起 差分信号运动模式与三个阶段一致 迁移运动复合体有趣的是，直接安装 葡萄糖进入空肠不会导致恢复到进食模式。 由于一名患者的胆碱能副作用，我们决定 停止使用乙酰胆碱作为分泌刺激， 前列腺素类似物。