Basic Problems of the Electrical Measurement of Biological Tissues

生物组织电学测量的基本问题

• 批准号: 10680803
• 负责人: KANAI Hiroshi
• 金额: $ 1.09万
• 依托单位: Sophia University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680803/
• 关键词: Electrical Properties; Biological Tissues; Electrical Measurement; Body Fluid Distribution; 生体組織の電気特性; β分散周波数; 細胞内液抵抗; 細胞外液抵抗; 細胞膜容量; 構造分散; 時定数; 3要素モデル; 浸透圧

Electrical properties of living tissues have been studied both theoretically and experimentally by many researchers. But even now, there are many problems which remain unsolved.Many researchers have tried to apply the electrical impedance method to clinical measurement and therapy, such as impedance Plethysmography, impedance cardiography, impedance CT, fluid volume measurement, hyperthermia, estimation of the effects of electromagnetic wave and so on. However, we have only a few impedance method which is sufficient and is widely and reliably used in clinical field. There are many causes for this problem. The most important problems is the lack of knowledge about biological tissues, because of the complexity of biological tissues. In this research, we discussed the electrical properties of cell suspension as a model of biological tissues. At first the electrical properties are theoretically discussed. And then the electrical characteristics of blood are experimentally investigated because of the simplicity of blood structure. These theoretical and experimental results could be widely used for the application of electrical method to clinical measurement and therapy. One of the most interesting applications of impedance method is the estimation of fluid distribution in the body. Especially the estimation of intra- and extra-cellular fluid distribution is very important for clinical diagnosis. This measurement method is based on β dispersion phenomenon. Therefore. frequency characteristics of the electrical properties of biological tissues should be well investigated.In this research, we theoretically discussed the electrical properties of cell suspension, and we could accurately measure the intra- and extra-cellular fluid distribution.

生物组织的电特性已经被许多研究者从理论和实验两方面进行了研究。但至今仍有许多问题没有得到解决，许多研究者试图将电阻抗方法应用于临床测量和治疗，如阻抗体积描记术、阻抗心动图、阻抗CT、液体体积测量、热疗、电磁波效应估计等，然而，我们只有少数几种阻抗方法，这是足够的，并广泛和可靠地应用于临床领域。造成这个问题的原因有很多。由于生物组织的复杂性，最重要的问题是缺乏对生物组织的了解。在本研究中，我们讨论了作为生物组织模型的细胞悬浮液的电学性质。首先从理论上讨论了其电学性质。由于血液的结构简单，本文对血液的电学特性进行了实验研究。这些理论和实验结果可为电学方法在临床测量和治疗中的应用提供参考。阻抗法最有趣的应用之一是估计体内的流体分布。特别是细胞内和细胞外液体分布的估计对于临床诊断非常重要。该测量方法基于β色散现象。因此。生物组织电特性的频率特性需要深入研究，本研究从理论上探讨了细胞悬液的电特性，并能准确测量细胞内和细胞外液的分布。

项目成果

藤井麻美子: "流れている血液の低周波電気特性"医用電子と生体工学. 37. 161-170 (1999)

Mamiko Fujii：“流动血液的低频电特性”《医疗电子与生物工程》37. 161-170 (1999)。

Katsayuki Sakamoto: "Study of the Relation between Fluid Distribution change and Impedance Change "Annals of the NY Academy of Sciences. 873. 77-88 (1999)

Katsayuki Sakamoto：“流体分布变化与阻抗变化之间关系的研究”纽约科学院年鉴。

Yongjun Lu: "Dielectric analysis of hen egg white with denaturation and in cool storage"Ine.J.of Food Science and Technology. 33. 393-399 (1999)

卢永军：“变性和冷藏鸡蛋清的介电分析”食品科学与技术杂志。

Mamiko Fujii: "Orientation and Deformation of Erythrocgtes in Flowing Blood."Annals of the NY Academg of Sciences. 873. 245-261 (1999)

Mamiko Fujii：“流动血液中红细胞的定向和变形。”纽约科学院年鉴。