COHERENCE NEAR-INFRARED UREA BREATH TEST ANALYZER

COHERENCE 近红外尿素呼气测试分析仪

• 批准号: 6016856
• 负责人: EDGAR A MENDOZA
• 金额: $ 10万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6016856
• 关键词: Helicobacter; biomedical equipment development; breath tests; communicable disease diagnosis; fiber optics; human subject; infrared radiation; semiconduction; technology /technique development; urea

Mounting evidence points toward Helicobacter pylori (formerly called Campylobacter pylori) as the cause of stomach and intestinal ulcers. Most people with ulcers harbor this bacteria, and eradicating the infection cures the disease, at least for a while. A broad spectrum of the population is at risk for H. pylori infection, but the elderly and people in developing countries are especially susceptible. The 13C-urea breath test (UBT) is currently the most accurate noninvasive method for the diagnosis of H. pylori infection. Intelligent Optical Systems (IOS) proposes to demonstrate a new, low-cost, portable near- infrared CNIR-UBT analyzer that a physician can be easily used in physician s offices or at patient bedsides in a hospitals. IOS s CNIR-UBT analyzer is based on two innovative technologies: (1) the creation of high spectral resolution optical fiber filters Bragg gratings that match precisely the spectra of 13CO2, and (2) the use of piezoelectric or electromagnetic stretchers to modulate the refractive index of optical fibers wound around them. All system components will be lightweight and compact, and will easily fit into a handheld or portable bench-top unit. PROPOSED COMMERCIAL APPLICATION IOS s CNIR-UBT analyzer represents a new, highly reliable, technology that will be available to physicians at an affordable price. IOS s CNIR-UBT analyzer is based on commercially available semiconductor and fiber optic technology that will allow the device to be mass produced at low costs. It is estimated that the potential American market for ulcer diagnosis is 150 million dollars per year. Right now endoscopy, a costly, invasive, procedure is the principal diagnostic option for detecting the H.pylori bacterium; this market is experiencing strong growth.

越来越多的证据表明幽门螺杆菌（以前称为幽门弯曲杆菌）是导致胃溃疡和肠道溃疡的原因。大多数患有溃疡的人体内都有这种细菌，根除这种感染至少可以暂时治愈这种疾病。广泛的人群都有感染幽门螺杆菌的风险，但老年人和发展中国家的人尤其容易感染。13c -尿素呼气试验（UBT）是目前诊断幽门螺杆菌感染最准确的无创方法。智能光学系统公司（Intelligent Optical Systems， IOS）提出了一种新型、低成本、便携式近红外CNIR-UBT分析仪，医生可以在医生办公室或医院的病人床边轻松使用。IOS的CNIR-UBT分析仪基于两项创新技术：(1)创建高光谱分辨率光纤滤波器布拉格光栅，精确匹配13CO2的光谱；(2)使用压电或电磁拉伸器来调制缠绕在它们周围的光纤的折射率。所有的系统组件将是轻量级和紧凑的，并将很容易地适合于手持或便携式台式设备。IOS的CNIR-UBT分析仪代表了一种新的、高度可靠的技术，将以可承受的价格提供给医生。IOS的CNIR-UBT分析仪基于商用半导体和光纤技术，这将使该设备能够以低成本批量生产。据估计，美国溃疡诊断的潜在市场每年为1.5亿美元。目前，内窥镜检查是检测幽门螺杆菌的主要诊断选择，这是一种昂贵的侵入性检查；这个市场正在经历强劲的增长。