NANOCOMPOSITE SURFACE FOR VERY LOW WEAR ORTHOPEDICS

用于极低磨损骨科的纳米复合材料表面

• 批准号: 6015534
• 负责人: ERIC J TOBIN
• 金额: $ 9.99万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015534
• 关键词: X ray crystallography; biomaterial development /preparation; biomaterial evaluation; ceramics; chemical synthesis; chromium; joint prosthesis; medical implant science; metal complex; nanotechnology; orthopedics; photoelectron spectrometry; scanning electron microscopy; surface coating; surface property; transmission electron microscopy

Generation of polyethylene wear debris from orthopedic prostheses is of major concern since it has been associated with osteolytic bone loss and, consequently, a reduction in joint lifetime. In large part due to this concern, metal/metal prostheses are being reconsidered for the articulating surfaces of hip and knee replacements. Wear of the metallic surfaces in this configuration is still of concern, particularly due to the questionable amount of lubrication available to the artificial joint. With the goal of minimizing wear and maximizing lifetime in metal/metal orthopedic systems, the proposed program will develop a unique metal matrix nanocrystalline composite surface. Such a material integrates the favorable wear characteristics of a ceramic with the inherent ductility, reliability, and adhesion of a metal. Metal matrix nanocrystalline composite surfaces will permit fabrication of more durable, reliable orthopedic prostheses with much longer effective lifetimes than conventional metal-on-polyethylene components. PROPOSED COMMERCIAL APPLICATIONS: More than 500,000 total and partial joint replacements are performed annually in the $1.8 billion U.S. orthopedic industry. Due to the link between polyethylene wear debris and osteolytic bone loss, alternatives to implants containing ultrahigh molecular weight polyethylene (UHMWPE) are being reconsidered, particularly in Europe. An orthopedic system that combines the benefits of ceramic and metal components and results in a wear rate that is two decades lower than with UHMWPE will be welcomed by manufacturers, surgeons, and patients.

骨科假体产生的聚乙烯磨屑是一个主要问题，因为它与溶骨性骨丢失相关，因此会缩短关节寿命。在很大程度上，由于这种担忧，金属/金属假体正在重新考虑用于髋关节和膝关节置换的关节面。在这种配置中，金属表面的磨损仍然令人担忧，特别是由于人造关节可用的润滑量值得怀疑。为了最大限度地减少金属/金属骨科系统的磨损和最大限度地延长使用寿命，该计划将开发一种独特的金属基纳米晶复合材料表面。这种材料将陶瓷良好的耐磨性与金属固有的延展性、可靠性和粘附性结合在一起。 金属基质纳米晶复合材料表面将允许制造更耐用、更可靠的骨科假体，其有效寿命比传统的金属对聚乙烯组件长得多。拟议的商业应用：在价值18亿美元的美国骨科行业中，每年进行超过50万次全关节和部分关节置换。 由于聚乙烯磨损碎屑与溶骨性骨丢失之间的联系，正在重新考虑含有超高分子量聚乙烯（UHMWPE）的植入物的替代品，特别是在欧洲。骨科系统结合了陶瓷和金属部件的优点，其磨损率比UHMWPE低二十年，将受到制造商、外科医生和患者的欢迎。