Efficacy of Thin HA Coatings Produced by a Novel Process

采用新工艺生产的薄 HA 涂层的功效

• 批准号: 6882011
• 负责人: ERIC J TOBIN
• 金额: $ 33.57万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882011
• 关键词: biomaterial compatibility; chemical structure; cold temperature; dental implants; dogs; hydroxyapatites; medical implant science; shear stress; surface coating; technology /technique development; tensile strength; titanium

DESCRIPTION: (provided by the applicant) This project is developing a new generation of calcium phosphate coatings for dental implants, in which film crystallinity is optimized for enhanced bioactivity and osseointegration. Phase I examined the hypothesis that optimal crystallinity leads to more rapid and stronger device fixation. Film crystallinities ranging from 30-90% were produced by a novel, low temperature deposition method and evaluated in a small animal model (rat). It was found that the ideal range was between 50-70% crystalline. These coatings provided bone-device integration compared to conventional plasma spray coatings. The purpose of the Phase II program is to further evaluate and demonstrate the advantage of calcium phosphate coatings with optimized crystallinity, as defined in Phase I. Both early and long-term bone response will be assessed in a large animal (canine) model, both prior to and after prosthesis loading. The desire to introduce this innovative technology to the field of dental implantology is based on two primary advantages of the process over existing technology used to apply HA coatings to implants. First, the chemical composition and crystallinity of the applied coating can be precisely controlled over a wide range of values, without the need for post deposition annealing. Second, the HA coatings can be deposited at low temperature as thin films from 1 to 5 mu/m thick, much thinner than coatings applied using plasma spray technology. Thinner coatings can provide a higher interfacial strength and better resistance than thicker plasma spray coatings.

描述：(由申请人提供)该项目正在开发用于牙科植入物的新一代钙磷酸盐涂层，其中薄膜的结晶度被优化以增强生物活性和骨整合。第一阶段检验了这样一种假设，即最佳结晶度会导致更快、更强的设备固定。用一种新的低温沉积方法制备了结晶度在30-90%之间的薄膜，并在小动物模型(大鼠)中进行了评估。研究发现，理想的结晶度范围在50-70%之间。与传统的等离子喷涂涂层相比，这些涂层提供了骨设备集成。 第二阶段计划的目的是进一步评估和展示第一阶段定义的结晶度优化的磷酸钙涂层的优势，早期和长期骨反应将在大型动物(犬)模型中进行评估，包括在假体加载之前和之后。将这一创新技术引入牙科植入学领域的愿望是基于该工艺相对于用于将HA涂层应用于种植体的现有技术的两个主要优势。首先，所涂涂层的化学成分和结晶度可以在很大范围内精确控制，而不需要后沉积退火。第二，HA涂层可以在低温下沉积成1~5MU/m厚的薄膜，比采用等离子喷涂技术的涂层要薄得多。与较厚的等离子喷涂层相比，较薄的涂层可以提供更高的界面强度和更好的耐磨性。