COMMERCIAL POTENTIAL FOR P26 IN VITRO AND IN VIVO

Expressive structures Inc.是一家小型服务型生物技术公司，成立于1998年，致力于解决蛋白质表达和液相色谱应用领域不断增长的创新发展需求。SBIR项目拨款的重点是开发一种新的细菌系统，该系统将显著提高可溶性和活性蛋白质的产量，其中许多可能被证明在健康相关应用中有用。新方法是利用来自虾的鲁棒和通用蛋白基因。研究将确定来自虾的蛋白质是否能帮助重组蛋白正确折叠，这些重组蛋白在大肠杆菌中表达时通常不溶。由于这些蛋白质还稳定易于聚集的蛋白质中间体，并抑制某些类别的蛋白酶，因此SBIR拨款的第二个目标是检查将这类蛋白质用于液相色谱应用的可行性。建议的商业应用：不可用

Expressive Constructs Inc. is a small service based biotechnology company that was founded in 1998 to address the growing need for innovative developments in protein expression and liquid chromatography applications. the focus of this SBIR project grant is to develop a novel system for bacteria that will dramatically improve the yield of soluble and active proteins, many of which may prove useful in health-related applications. The novel approach is to utilize robust and general purpose protein genes from shrimp. It will be determined whether proteins from shrimp can assist proper folding of recombinant proteins that are not normally soluble when expressed in E. coli. Since these proteins also stabilize aggregation-prone protein intermediates, and inhibit certain classes of proteases, the second goal of this SBIR grant is to examine the feasibility of using this class of proteins for liquid chromatography applications. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE