DECONVOLUTION MODELING TOOL FOR SAAM II

SAAM II 的反卷积建模工具

• 批准号: 2713849
• 负责人: DAVID M FOSTER
• 金额: $ 9.96万
• 依托单位: SAAM INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2713849
• 关键词: chemical kinetics; computer graphics /printing; computer program /software; computer simulation; computer system design /evaluation; mathematical model

The overall objective of our proposal is to design and implement a general deconvolution tool in the SAAM II software system. Deconvolution is a method used to estimate input into a system, such as the rate of appearance of a drug in plasma after an oral administration or the secretion rate of a gland, since these input fluxes are usually not directly measurable in vivo. A tool to estimate these exogenous and endogenous fluxes inputs is essential for a quantitative understanding of the kinetics of drugs, hormones and substrates in the body in both healthy and disease states. A novel nonparametric stochastic deconvolution approach has been developed under the aegis of an R-01 grant from BTP/NCRR which is able to cope with the peculiarities of pharmacokinetic/physiological systems. New numerical algorithms based on a singular value decomposition strategy permit the solution of high-dimensional deconvolution problems. The theory and algorithms have been prototyped and tested. The purpose of our proposed project is to implement the deconvolution tool in the SAAM II software system, and to make it easily available to the user via the graphical use interface. PROPOSED COMMERCIAL APPLICATION: SAAM II is a powerful, general purpose simulation software package widely used in pharmaceutical and medical research. Many investigators using the software want to be able to estimate inputs into the systems they are studying under various experimental inputs. Deconvolution is a tool used to do this. Making this tool easily available should have a considerable impact on our current and potential user communities.

我们建议的总体目标是设计和实施一个通用的 SAAM II软件系统中的反卷积工具。反卷积是一个 一种用于估计系统输入的方法，如 口服给药后血浆中药物的出现或 腺体的分泌速率，因为这些输入通量通常不是 可直接在体内测量。一个工具来估计这些外源和 内源通量输入对于定量了解 药物，激素和底物在体内的动力学在两个健康 和疾病状态。 提出了一种新的非参数随机反褶积方法 在BTP/NCRR的R-01赠款的支持下， 药代动力学/生理系统的特性。新的数值 基于奇异值分解策略的算法允许 解决高维反卷积问题。理论与 算法已经被制成原型并经过测试。我们建议的目的是 项目是在SAAM II软件中实现反卷积工具 系统，并使其易于通过图形使用提供给用户 接口. 拟定商业应用： SAAM II是一个功能强大的通用仿真软件包， 用于制药和医学研究。许多研究人员使用 软件希望能够估计系统的输入， 在不同的实验输入下进行研究。反卷积是一种工具， 这么做使这个工具容易获得应该有相当大的 对我们当前和潜在用户社区的影响。