EFFECT OF ETHANOL ON LIPOPROTEIN KINETICS ASSESSED BY POPULATION ANALYSIS

这个协作项目的具体目标是将 此应用程序中描述的新方法以获得更准确的 估计两个最小模型的总体参数，从而 正常、肥胖和肥胖患者的葡萄糖代谢和β细胞功能 胰岛素依赖型糖尿病(NIDDM)受试者。除了提供 总体参数和协方差矩阵，这些分析还将 允许我们考虑协变量。例如，肥胖是 重视认识葡萄糖处置与组织损伤的关系 胰岛素分泌参数和人体测量变量。 内脏肥胖症(TAC测量)。在NIDDM中，一个主要问题是 理解葡萄糖处理和处理的综合关系 与其他关键变量相关的胰岛素分泌参数 如血压、甘油三酯和内脏FFA水平。 这些协变量将包括在人口分析中，并将 有助于我们理解大血管/微血管并发症 特兹。

The specific aims of this collaborative projecxt are to apply the new methods described in this aplication to obtain more accurate estimated of the population parameters of both minimal models and thus of both glucose disposal and beta-cell function in norma, obese and mominsulin-dependetn (NIDDM) subjects. Besides providing the population parameters and covariance matrix, these analyses will also permit us to indlude the covariates. For example, obesity is importnat in understanding the relation between glucose disposal and insulin secretion parameters and anthropometric variables, e.g. visceral adiposity (measured by TAC). In NIDDM, a major issue is to understand the integrated relation between glucose disposal and insulin secretion parameters in the light of other crucial variables such as blood pressure, triglyceride and FFA levels of visceral. These covariates will be included in the population analyses, and will help in our understanding of macrovascular/microvascular complita tions.