RETINAL SPECTROFLUOROMETER

视网膜荧光分光计

• 批准号: 2651389
• 负责人: Bruce M Ishimoto
• 金额: $ 9.21万
• 依托单位: OCUMETRICS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1999-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651389
• 关键词: biomedical equipment development; clinical biomedical equipment; fluorescence; human subject; lipofuscin; microspectrophotometry; retina

DESCRIPTION: The investigator goal is to develop a commercial instrument for measuring and characterizing intrinsic fluorescence (autofluorescence) in the retina. This instrument will make it possible to broaden the research connecting lipofuscin - the dominant retinal fluorophore - with aging, age related macular degeneration (AMD), and several juvenile retina degenerations. Lipofuscin also is thought to reflect oxidative damage to the retina and its quantification would provide a cumulative index of oxidative damage to the retina. The Pi sees a market for such a device among retinal researchers and pharmaceutical companies. Furthermore, an instrument designed specifically for retinal spectrofluorometry will allow the study of other retial fluorophores (collagen, drusen, flavi proteins) as well as open the possibility of quantitative studies using exogenous fluorescent markers (fluorescein , ICG, BPD, etc). PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：研究者的目标是开发一种商业 用于测量和表征固有荧光的仪器 （autofluorescence）在视网膜。 这个仪器可以让我们 为了拓宽脂褐素--视网膜色素瘤的主要成分-- 荧光团-与衰老，年龄相关性黄斑变性（AMD），和 几次青少年视网膜变性。 脂褐素也被认为 反映了视网膜的氧化损伤，其定量将 提供视网膜氧化损伤的累积指数。 的Pi 在视网膜研究人员中看到了这种设备的市场， 制药公司。 此外，设计的仪器 专门用于视网膜荧光分光光度法将允许研究 其它的荧光团（胶原蛋白、玻璃疣、黄蛋白）以及 打开了使用外源荧光定量研究的可能性 标记物（荧光素、ICG、BPD等）。 拟议商业应用：不可用