NEW POLYMER PHASES FOR EFFICIENT HPLC

本项目的目标是制备新型聚合物固定相， 高效液相色谱法比聚苯乙烯色谱法更有效- 二乙烯基苯 该方法将合成一种聚合物， 主要是交替的亲水和疏水单元。 的 这些单位的结构和它们的相对浓度将是 调节以产生在膨胀过程中具有类似膨胀趋势的材料， 极性和非极性溶剂。 因此，这种材料可以 多孔的，不会随着移动的相的变化而膨胀或收缩 混合物. 它将不必是高度交联和刚性的， 聚苯乙烯-二乙烯基苯。 这将改善色谱 因为通过聚合物相的传质速率 将比聚苯乙烯-二乙烯基苯更快。 具体目标 第一阶段的目标是通过以下方式证明这种方法的可行性： 制备聚合物固定相，其产生4的缩小板 或更少，同时保持与商业上类似的稳定性和容量 可用列。 在第二阶段， 将进一步探讨这些阶段。 建议的商业应用 反相HPLC色谱柱的全球市场是数百个 百万美元。 这个项目的成功将使芬里斯技术公司 Research，Inc.能够在这方面占有很大份额 市场

The goal of this project is to prepare new polymer stationary phases for HPLC that yield more efficient chromatography than polystyrene- divinylbenzene. The approach will be synthesize a polymer consisting predominantly of alternating hydrophilic and hydrophobic units. The structures of these units and their relative concentrations will be adjusted to produce a material that has similar swelling tendencies in both polar and nonpolar solvents. Therefore, this material can be porous without tending to swell or shrink with changing mobile phase composition. It will not have to be as highly crosslinked and rigid as polystyrene-divinylbenzene. This will improve chromatographic efficiency because the rate of mass transfer through the polymer phase will be faster thatn with polystyrene-divinylbenzene. The specific aim of Phase I is to demonstrate the feasibility of this approach by preparing a polymer stationary phase that yields a reduced plate of 4 or less while retaining stability and capacity similar to commercially available columns. In Phase II, the chromatographic characteristics of these phases will be further explored. PROPOSED COMMERCIAL APPLICATION The worldwide market for reversed phase HPLC columns is several hundred million dollars. Success in this project would put Fenris Technology Research, Inc., in position to capture a significant share of this market.