SWEET PREFERENCE AND FAMILY HISTORY OF ALCOHOLISM

甜食偏好和酗酒家族史

• 批准号: 6097747
• 负责人: VINSTON GOLDMAN
• 金额: $ 12.5万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6097747
• 关键词: African American; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; cooperative study; dietary carbohydrates; disease /disorder etiology; disease /disorder proneness /risk; family genetics; genetic markers; human subject; interview; male; neurobiology; preference; psychophysiology; statistics /biometry; young adult human (21-34)

Alcoholism, a major public health problem, has been shown to have a partly genetic origin which creates a theoretical basis for the search for.biological phenotypic markers for this disease. Identification of such markers could advance understanding of the pathophysiological basis of alcoholism and, perhaps, lead to the development of new methods of determination of biological vulnerability for alcoholism at an early age. A preference for sweets has been shown to strongly correlate with a preference for alcohol in genetic animal models of heavy alcohol intake. Results of a pilot human study have shown that 65 % of Caucasian male alcoholics prefer the highest concentration of sucrose offered, 0.83M, in a sweet preference test compared to only 16% of Caucasian, male nonalcoholics, Fisher's exact test p= .0003. The purpose of the present proposal is to carefully test the hypothesis that sweet liking, a robust and reliable psychophysical measure, reflects a genetic vulnerability for alcoholism. This hypothesis will be tested by examining whether sweet liking is more prevalent in a cohort of 50 nonalcoholic subjects with high genetic risk for alcoholism than in 50 nonalcoholic subjects with low genetic risk for alcoholism. This study will be focused on an African American sample which has been underrepresented in previous studies involving association between alcoholism and sweet preference. The subjects will be recruited at North Carolina Central University in Durham, NC. Because sweet liking may be a neurobiologically determined trait, demonstrating linkage between sweet liking and alcoholism may advance the understanding of the pathophysiology of alcoholism, and thereby advance understanding of the pathophysiology of alcoholism, and thereby advance understanding of the etiology and treatment of this destructive disorder.

酗酒是一个主要的公共卫生问题， 一个部分遗传的起源，创造了理论基础， 寻找这种疾病的生物表型标记。 识别这些标记物可以促进对 酒精中毒的病理生理基础，也许，导致 生物测定新方法的发展 在很小的时候就容易酗酒。倾向于 研究表明，甜食与人们对 酒精在大量摄入酒精的遗传动物模型中的作用。结果 一项初步的人类研究表明，65%的白人男性 酗酒者喜欢所提供的最高浓度的蔗糖， 0.83 M，在甜食偏好测试中，与白人的16%相比， 男性非酗酒者，Fisher精确检验p= 0.0003。的目的 目前的建议是仔细测试的假设，甜 喜欢，一个强大而可靠的心理物理测量，反映了一个 酗酒的遗传弱点这一假设将得到检验 通过研究是否喜欢甜食在一个队列中更普遍， 50名非酒精性受试者，酒精中毒遗传风险高， 在50名酗酒遗传风险较低的非酒精受试者中。 这项研究将集中在一个非裔美国人的样本， 在之前涉及关联的研究中代表性不足 酒精中毒和甜食偏好之间的关系受试者将 在北卡罗来纳州达勒姆的北卡罗来纳州中央大学招募。 因为喜欢甜食可能是一种神经生物学决定的特征， 表明喜欢甜食和酗酒之间的联系可能 促进对酒精中毒病理生理学的理解， 从而促进对酒精中毒的病理生理学的理解， 从而促进对病因学和治疗的理解， 这种破坏性的紊乱