SWEET PREFERENCE AND FAMILY HISTORY OF ALCOHOLISM

甜食偏好和酗酒家族史

• 批准号: 6200927
• 负责人: VINSTON GOLDMAN
• 金额: $ 12.5万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6200927
• 关键词: African American; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; cooperative study; dietary carbohydrates; disease /disorder etiology; disease /disorder proneness /risk; family genetics; genetic markers; human subject; interview; male; neurobiology; preference; psychophysiology; statistics /biometry; young adult human (21-34)

Alcoholism, a major public health problem, has been shown to have a partly genetic origin which creates a theoretical basis for the search for.biological phenotypic markers for this disease. Identification of such markers could advance understanding of the pathophysiological basis of alcoholism and, perhaps, lead to the development of new methods of determination of biological vulnerability for alcoholism at an early age. A preference for sweets has been shown to strongly correlate with a preference for alcohol in genetic animal models of heavy alcohol intake. Results of a pilot human study have shown that 65 % of Caucasian male alcoholics prefer the highest concentration of sucrose offered, 0.83M, in a sweet preference test compared to only 16% of Caucasian, male nonalcoholics, Fisher's exact test p= .0003. The purpose of the present proposal is to carefully test the hypothesis that sweet liking, a robust and reliable psychophysical measure, reflects a genetic vulnerability for alcoholism. This hypothesis will be tested by examining whether sweet liking is more prevalent in a cohort of 50 nonalcoholic subjects with high genetic risk for alcoholism than in 50 nonalcoholic subjects with low genetic risk for alcoholism. This study will be focused on an African American sample which has been underrepresented in previous studies involving association between alcoholism and sweet preference. The subjects will be recruited at North Carolina Central University in Durham, NC. Because sweet liking may be a neurobiologically determined trait, demonstrating linkage between sweet liking and alcoholism may advance the understanding of the pathophysiology of alcoholism, and thereby advance understanding of the pathophysiology of alcoholism, and thereby advance understanding of the etiology and treatment of this destructive disorder.

酗酒是一个主要的公共卫生问题，已被证明会导致 部分遗传起源为 寻找这种疾病的生物表型标记。 识别这些标记可以促进对 酗酒的病理生理学基础，并可能导致 开发测定生物活性的新方法 年轻时容易酗酒。偏好 甜食已被证明与偏好密切相关 大量饮酒的遗传动物模型中的酒精。结果 一项人类试点研究表明，65% 的白人男性 酗酒者更喜欢提供最高浓度的蔗糖， 0.83M，在一项甜味偏好测试中，相比之下只有 16% 的白种人， 男性非酗酒者，Fisher 精确检验 p= .0003。目的 目前的建议是仔细检验甜的假设 喜欢是一种强大而可靠的心理物理测量方法，反映了 酗酒的遗传脆弱性。这个假设将被检验 通过检查在一群人中是否更普遍喜欢甜食 50 名非酒精受试者具有较高的酗酒遗传风险 在 50 名酒精中毒遗传风险较低的非酒精受试者中进行了研究。 这项研究将重点关注非裔美国人样本 在之前涉及关联的研究中代表性不足 酒精中毒和甜食偏好之间。科目将是 在北卡罗来纳州达勒姆的北卡罗来纳中央大学招募。 因为喜欢甜食可能是一种神经生物学决定的特征， 证明甜食喜好与酗酒之间的联系可能 增进对酗酒病理生理学的理解，以及 从而增进对酗酒病理生理学的理解， 从而增进对病因和治疗的了解 这种破坏性的紊乱。