AUTOMATED GAS ENHANCED VASCULAR IMAGING

自动气体增强血管成像

• 批准号: 6020400
• 负责人: ELVIRA Valentina LANG-ANDERSON
• 金额: $ 11.03万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6020400
• 关键词: biomedical automation; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; computed axial tomography; contrast media; diagnosis design /evaluation; magnetic resonance imaging; method development; pulmonary circulation obstruction; radionuclides; respiratory disorder diagnosis; respiratory imaging /visualization; swine; xenon

Intravascular injection of contrast solutions is the de facto standard method for diagnosis of vasoocclusive disease. These agents have osmolar, chemotoxic, and anaphylactic risks. Substitution of gas as contrast medium has significant potential to avoid these recognized limitations of conventional contrast media solutions with high safety. Automated intravascular injection of various gases enables the development of novel imaging approaches with multiple imaging modalities (CT, ultrasound, MRI, and others). In particular, sequential and concomitant accumulation of intravenously injected gases in the pulmonary microvasculature and in the alveoli during single breath-hold offers a potential self-enhancing mechanism for direct perfusion imaging. We propose to develop an instrument for safe intravenous gas injection of gases in simulations and in the pulmonary vasculature of animals. Our goal is to realize the potential of automated gas injection as an alternative to liquid intravascular contrast and achieve greater safety, better imaging performance, and possible reduction or elimination of radiation. The performance of a prototype gas injector will be tested for reliable and safe delivery of CO2, nonpolarized stable Xe, and hyperpolarized Xe in an ex-vivo flow circuit. In vivo imaging performance will be evaluated and optimized using temporal Volumetric Image Display and Analysis in pigs without and with pulmonary emboli. Electron beam cine-CT will be used with injections of CO2 and stable Xe, MRI will be used with injections of hyperpolarized Xe. On completion, this project will provide a well characterized automated gas injection device with known imaging performance on administration of various gases. This device should find application for assessment of pulmonary embolism with contrast angiography when noninvasive and potentially radiation free three- dimensional vascular imaging modalities are preferred. The methodology can be expanded to gas- enhanced imaging of the entire vasculature and endoluminal gas-enhanced therapeutic applications.

血管内注射造影剂是事实上的标准 血管闭塞性疾病的诊断方法。 这些药物 渗透压、化学毒性和过敏性风险。气体替代为 造影剂有很大的潜力，以避免这些公认的 具有高安全性的常规造影剂溶液的局限性。 各种气体的自动血管内注射使得 开发具有多种成像模式的新型成像方法 (CT超声、MRI和其它）。 特别是，顺序和 伴随的静脉内注射气体的积聚 单次屏气时肺微血管和肺泡中的 为直接灌注提供了潜在的自我增强机制 显像 我们建议开发一种用于安全静脉气体注射的仪器 模拟和动物肺血管中的气体。 我们的目标是实现自动气体注入作为一种 替代液体血管内造影剂并实现更大的安全性， 更好的成像性能，并可能减少或消除 辐射 将测试原型气体喷射器的性能 用于可靠和安全地输送CO2、非极化稳定的CO2，以及 在离体流动回路中的超极化。 体内成像 性能将使用时间容量进行评估和优化 无和有肺栓塞猪的图像显示和分析。 电子束电影CT将与CO2和稳定的二氧化碳注射一起使用， MRI将与注射超极化MRI一起使用。 完成后，该项目将提供一个良好的特点自动化 具有已知给药成像性能的气体注射装置 各种气体。 该器械应适用于评估 非侵入性肺栓塞的造影剂血管造影， 潜在无辐射三维血管成像 模式是首选。该方法可以扩展到气体- 整个脉管系统的增强成像和腔内气体增强 治疗应用。