Midcareer Development in Nonpharmacologic Analgesia

替代医疗方法得到公众的广泛接受，但很少被纳入传统医疗实践。在《柳叶刀》发表的同类最大的前瞻性随机研究中，候选人表明，在侵入性医疗程序中以自我催眠放松形式的非药物镇痛显著减少了患者的疼痛焦虑、药物使用、并发症数量、血流动力学不稳定性和手术时间。这将节省大量资源。候选人的直接目标是扩展和验证跨学科综合替代/传统医疗保健服务的概念。长期目标是从科学研究到临床环境中急性非药物镇痛的普遍实施的成功过渡。该候选人处于实现国家目标的独特位置：在实验室和临床研究方面的坚实基础以及她作为国际放射学主任的职位为她提供了必要的可信度，以促进和实施侵入性医疗程序期间的身心干预。她被传统医学和身心导向的专业团体所接受，使她的方法能够融入两个社区。候选人的RO 1和国防部的资金集中在评估非药物镇痛在侵入性血管程序和大核心乳房活检。根据拟议的职业中期奖，她将（1）在传统临床环境中引入和质量评估非药物镇痛技术方面获得权威专业知识（2）在新成立的哈佛大学研究和教育以及补充和综合医学治疗部门中发挥关键作用，以及（3）指导下一代研究人员和从业人员在这一领域。为了实现这些目标，候选人将获得教育技术，质量评估和网络传播方面的额外研究技能;获得额外补充和替代疗法的专业知识;并将在充分监测的临床环境中向其他研究人员提供数据库，想法，经验和患者。她将承担主要指导责任，共15开始临床研究人员。完成后，候选人将确立自己作为引进和质量评估相结合的替代/传统医疗做法的权威。指导开始临床研究人员将有助于培养一个自我维持的模式，在未来的综合实践。

Alternative medical methods enjoy broad acceptance by the public, but are rarely integrated into conventional medical practice. In the largest prospective randomized study of its kind, published by the Lancet, the candidate showed that non-pharmacologic analgesia in the form of self- hypnotic relaxation during invasive medical procedures significantly reduces patients' pain anxiety, drug use, number of complications, hemodynamic instability, and procedure time. This results in substantial resource savings. The immediate goal of the candidate is to expand and validate this concept of integrated alternative/conventional health care delivery across disciplines. The long-term goal is the successful transition from scientific investigation to general implementation of acute non-pharmacologic analgesia in clinical settings. The candidate is uniquely situated to achieve the state goals: A strong foundation in laboratory and clinical research as well as her position as Director of International Radiology provides her the necessary credibility to promote and implement mind body intervention during invasive medical procedures. Her acceptance by both conventional medical and mind-body oriented professional societies permit integration of her methods into both communities. The candidate's RO1 and DOD funding focuses on assessment on non-pharmacologic analgesia during invasive vascular procedures and during large core breast biopsy. Under the proposed mid-career award, she will (1) acquire authoritative expertise in the introduction and quality assessment of non- pharmacologic analgesia techniques in conventional clinical settings (2) assume a key role in the newly established Harvard-wide Division for Research and Education and Complementary and Integrative Medical Therapies, and (3) mentor the next generation of researchers and practitioners in this field. Towards these aims the candidate will acquire additional research skills in educational technology, quality assessment, and web-based dissemination; acquire expertise in additional complementary and alternative therapies; and will make available to other researchers data banks, ideas, experience and patients in fully monitored clinical environment. She will assume primary mentoring responsibility for a total of 15 beginning clinical researchers. Upon completion, the candidate will have established herself as an authority in the introduction and quality assessment of combined alternative/conventional medical practices. The mentoring of beginning clinical researchers will have contributed towards fostering a self- sustaining mode of integrated practice in the future.