OXYGENATION OF BLOOD BY LIQUID INFUSION

通过液体输注使血液充氧

• 批准号: 2827381
• 负责人: GILES J BRERETON
• 金额: $ 9.54万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2827381
• 关键词: biomaterial interface interaction; blood /plasma substitute; blood oxygenator; injection /infusion; method development; oxygen tension; oxygen transport

The technology to be developed in this study would enable oxygenation of blood by intra-aortic infusion of a highly oxygenated carrier liquid. The liquid would be oxygenated at sufficiently high concentrations (10 - 40 cm3 dissolved gaseous oxygen/gram liquid) that, after infusion, the blood oxygen content would be raised to the levels achieved through the normal respiratory function of the lungs, with a low enough fluid load to allow long-term systemic applications. This approach provides an alternative to the existing paradigm that systemic or regional tissue hypoxia is only correctable by diffusion of oxygen across an interface (lungs/artificial membrane) between gas and the systemic blood volume. In the proposed approach, by using oxygen pre-dissolved in a carrier liquid which is delivered so as to suppress nucleation, oxygenation is accomplished by the more efficient mechanism of liquid-liquid mixing. The approach has applications to treatments of tissue hypoxia which span a wide range of pathophysiologic problems in medicine and surgery. To achieve nucleation-free delivery and mixing of oxygenated solutions at the required oxygen concentration, experimental and theoretical research is needed on the preparation of gas-supersaturated solutions, their delivery along capillary tubes, and their mixing with co-flowing blood at the distal tube-end. Techniques for preparing stable oxygen- supersaturated liquids and nucleation theories, developed by the principal investigators in earlier work to explain suppression of nucleation during transport along micron-size capillary tubeses, will be extended to preparation of oxygenated solutions at much higher concentrations and to understanding thresholds for nucleation during transport along sub-micron capillary tubes. The research needed in these areas is critical to achieving safe oxygenation by liquid-liquid mixing at the desired oxygen levels.

这项研究将开发的技术将使氧气 通过主动脉内输注高含氧量的载体液体来输血。 液体将在足够高的浓度下被氧化(10- 40立方米溶解气态氧/克液体)，输液后， 血氧含量将提高到通过 肺的正常呼吸功能，有足够低的液体负荷 以允许长期的系统性应用。这种方法提供了一种 替代现有的全身性或区域性组织 缺氧只能通过在界面上扩散氧气来纠正 (肺/人工膜)气体和全身血容量之间。 在所提出的方法中，通过使用载体中预溶的氧 为抑制形核、氧化作用而输送的液体 这是通过更有效的液液混合机制实现的。 该方法可应用于跨度组织缺氧的治疗。 内科和外科中广泛的病理生理学问题。至 实现含氧溶液的无核输送和混合 所需氧气浓度、实验和理论研究 在制备气体过饱和溶液时需要，他们的 毛细管输送及其与顺流血液的混合 在远端的管端。制备稳定氧的技术- 过饱和液体和成核理论，由 首席调查人员在早期的工作中解释了对 沿微米级毛细管输送过程中的成核作用 扩展到在更高的温度下制备含氧溶液 浓度和理解成核阈值 沿着亚微米毛细管输送。年所需的研究 这些区域对于实现液-液安全氧合至关重要。 在所需的氧气水平下混合。