OXYGENATION OF BLOOD BY LIQUID INFUSION

通过液体输注使血液充氧

• 批准号: 6056610
• 负责人: GILES J BRERETON
• 金额: $ 8.29万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6056610
• 关键词: biomaterial interface interaction; blood /plasma substitute; blood oxygenator; injection /infusion; method development; oxygen tension; oxygen transport

The technology to be developed in this study would enable oxygenation of blood by intra-aortic infusion of a highly oxygenated carrier liquid. The liquid would be oxygenated at sufficiently high concentrations (10 - 40 cm3 dissolved gaseous oxygen/gram liquid) that, after infusion, the blood oxygen content would be raised to the levels achieved through the normal respiratory function of the lungs, with a low enough fluid load to allow long-term systemic applications. This approach provides an alternative to the existing paradigm that systemic or regional tissue hypoxia is only correctable by diffusion of oxygen across an interface (lungs/artificial membrane) between gas and the systemic blood volume. In the proposed approach, by using oxygen pre-dissolved in a carrier liquid which is delivered so as to suppress nucleation, oxygenation is accomplished by the more efficient mechanism of liquid-liquid mixing. The approach has applications to treatments of tissue hypoxia which span a wide range of pathophysiologic problems in medicine and surgery. To achieve nucleation-free delivery and mixing of oxygenated solutions at the required oxygen concentration, experimental and theoretical research is needed on the preparation of gas-supersaturated solutions, their delivery along capillary tubes, and their mixing with co-flowing blood at the distal tube-end. Techniques for preparing stable oxygen- supersaturated liquids and nucleation theories, developed by the principal investigators in earlier work to explain suppression of nucleation during transport along micron-size capillary tubeses, will be extended to preparation of oxygenated solutions at much higher concentrations and to understanding thresholds for nucleation during transport along sub-micron capillary tubes. The research needed in these areas is critical to achieving safe oxygenation by liquid-liquid mixing at the desired oxygen levels.

本研究中开发的技术将使氧合 通过主动脉内输注高氧载液来收集血液。 液体将在足够高的浓度下被氧化（10 - 40 cm3 溶解气氧/克液体），输注后， 血氧含量将提高到通过以下方法达到的水平 肺部呼吸功能正常，液体负荷足够低 以允许长期系统应用。 这种方法提供了一种 现有范式的替代方案是系统性或区域性组织 缺氧只能通过氧气穿过界面扩散来纠正 （肺/人工膜）气体和全身血量之间。 在所提出的方法中，通过使用预溶解在载体中的氧气 输送液体以抑制成核，氧化是 通过更有效的液-液混合机制来完成。 该方法可应用于组织缺氧的治疗，其范围涵盖 医学和外科领域广泛的病理生理学问题。 到 实现含氧溶液的无核输送和混合 所需的氧气浓度、实验和理论研究 制备气体过饱和溶液时需要，它们 沿着毛细管输送，并与同流血液混合 在远端管端。稳定氧的制备技术 过饱和液体和成核理论，由 主要研究人员在早期工作中解释了压制 沿着微米尺寸的毛细管运输期间成核，将 扩展到在更高温度下制备含氧溶液 浓度并了解成核过程中的阈值 沿着亚微米毛细管运输。 需要进行的研究 这些区域对于实现液-液安全氧合至关重要 在所需的氧气水平下混合。