PATHLENGTH RESOLVED NONINVASIVE OPTICAL GLUCOSE SENSORS

描述(改编自申请人的摘要)：本报告的目的 建议是研究用于监测的相干光学技术 葡萄糖浓度。拟议的进步利用了 光学相干层析成像(OCT)的固有光路选择性， 一种新开发的定量、非侵入性组织技术 基于低相干光干涉的传感和成像。方法： 监测组织的折射率、散射和偏振变化 其特征在于对采样组织路径进行显式控制 长度。该提案的具体目的是：1)检验可行性 微米级路径的三个新概念--长度分辨、非侵入性 基于光学相干性自适应的光学血糖传感 断层扫描(OCT)，2)将测量结果与实际血糖相关联 简单和日益复杂的组织液模型中的浓度，如 在接受葡萄糖挑战测试的人类志愿者中也是如此。每一个 建议的技术方法是完全非侵入性的，不需要 抽出血液或皮下液体，不需要一次性使用 酶的补给或补给。

DESCRIPTION (Adapted from applicant's abstract): The objective of this proposal is to investigate coherent optical technology for monitoring glucose concentration. The proposed advances take the advantage of the intrinsic optical path selectivity of optical coherence tomography (OCT), a recently developed technology for quantitative, non-invasive tissue sensing and imaging based on low-coherence interferometry. Methods for monitoring tissue index of refraction, scattering and polarization changes are proposed which feature explicit control over sampled tissue path length. The specific aims of the proposal are to: 1) test the feasibility of three new concepts for micron-scale path-length-resolved, non-invasive optical glucose sensing based upon adaptations of optical coherence tomography (OCT), 2) correlate the measurements with actual glucose concentrations in simple and increasingly complex tissue fluid models, as well as in human volunteers undergoing glucose challenge tests. Each of the proposed technical approaches is completely non-invasive, requiring no withdrawal of blood or subcutaneous fluid and do not require disposable supplies or re-stocking of enzymes.