Motion Artifact Reduced SDOCT of the Anterior Segment

运动伪影减少了眼前节的 SDOCT

• 批准号: 8007353
• 负责人: JOSEPH A IZATT
• 金额: $ 18.72万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007353
• 关键词: Accounting; Adoption; Adult; Age; Algorithms; Anterior; Cataract Extraction; Clinical; Computer software; Cornea; Corneal Topography; Data; Dependence; Development; Devices; Diagnosis; Event; Eye; Image; Imaging Device; Intervention; Intraocular lens implant device; Keratoplasty; Lasers; Light; Maps; Measurement; Measures; Methods; Metric; Morphologic artifacts; Motion; Operative Surgical Procedures; Optical Coherence Tomography; Outcome; Pathological Dilatation; Patients; Performance; Procedures; Relative (related person); Resolution; Shapes; Speed; Surface; System; Technology; Testing; United States; Validation; Visual; base; care delivery; clinical application; design; improved; innovation; instrument; instrumentation; new technology; novel; public health relevance; software development; tomography

DESCRIPTION (provided by applicant): Accurate quantitative imaging of the cornea is critical for predictable outcomes in corneal based surgical interventions. While long the standard, reflection based corneal topography to assess corneal curvature and refractive power is insufficient in an era when surgical manipulation of the corneal shape is routine and undermines the basis of reflection topography. Laser refractive surgery is one particular corneal intervention that has revealed current inadequacies in measuring the cornea. Over 7 million people in the United States have had some form of laser refractive surgery to reduce their dependence on corrective eye wear. The corneal reshaping that occurs from laser refractive surgery results in excellent visual results for the patient but renders current technologies incapable of accurately measuring the power of the reshaped cornea. Accurate measurement of corneal power is critical in applications such as the prediction of intraocular lens power needed after cataract surgery, an event which this group of patients will invariably encounter as they age into late adulthood. Our proposed development of a motion corrected high-speed spectral domain optical coherence tomography (SDOCT) based device which can directly map corneal surfaces at micron resolution and then accurately convert this data to keratometric values will greatly aid clinical applications dependent on this value. The primary innovations will be the development of novel hardware and software methods to account for involuntary patient motion and for refraction of OCT light within the cornea. A clinical comparison will then be made in patients undergoing laser refractive surgery to compare the measurements made by SDOCT versus existing clinical instrumentation for the measurement of corneal power. PUBLIC HEALTH RELEVANCE: We propose to develop an improved ocular anterior segment imaging system using spectral domain optical coherence tomography. If successful, this project could support widespread adoption of SDOCT as the preferred, single-platform anterior segment imaging device in eye care delivery.

描述（由申请人提供）：角膜的准确定量成像对于基于角膜的手术干预的可预测结局至关重要。虽然长期以来，标准的，基于反射的角膜地形图评估角膜曲率和屈光力是不够的，在一个时代，手术操作的角膜形状是常规的，并破坏了反射地形图的基础。激光屈光手术是一种特殊的角膜干预，它揭示了目前测量角膜的不足之处。在美国，超过700万人接受了某种形式的激光屈光手术，以减少对矫正眼镜的依赖。由激光屈光手术发生的角膜整形为患者带来了极好的视觉效果，但使得当前技术不能准确地测量整形角膜的屈光力。角膜屈光力的精确测量在诸如白内障手术后所需的眼内透镜屈光力的预测的应用中是关键的，这类患者随着年龄增长到成年后期将不可避免地遇到这种情况。我们建议开发一种基于运动校正的高速谱域光学相干断层扫描（SDOCT）的设备，该设备可以以微米分辨率直接映射角膜表面，然后将该数据准确地转换为角膜曲率值，这将极大地帮助依赖于该值的临床应用。主要创新将是开发新的硬件和软件方法，以解释患者的非自主运动和角膜内OCT光的折射。然后将在接受激光屈光手术的患者中进行临床比较，以比较SDOCT与现有临床仪器测量角膜屈光力的结果。 公共卫生相关性：我们建议开发一种改进的眼前节成像系统，使用光谱域光学相干断层扫描。如果成功，该项目可以支持SDOCT作为眼科护理中首选的单平台眼前节成像设备的广泛采用。

项目成果

Distributed scanning volumetric SDOCT for motion corrected corneal biometry.

• DOI: 10.1364/boe.3.002050
• 发表时间: 2012-09-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: McNabb RP;Larocca F;Farsiu S;Kuo AN;Izatt JA
• 通讯作者: Izatt JA

Corneal biometry from volumetric SDOCT and comparison with existing clinical modalities.

• DOI: 10.1364/boe.3.001279
• 发表时间: 2012-06-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Kuo AN;McNabb RP;Zhao M;Larocca F;Stinnett SS;Farsiu S;Izatt JA
• 通讯作者: Izatt JA

Optical coherence tomography accurately measures corneal power change from laser refractive surgery.

• DOI: 10.1016/j.ophtha.2014.10.003
• 发表时间: 2015-04
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: McNabb, Ryan P.;Farsiu, Sina;Stinnett, Sandra S.;Izatt, Joseph A.;Kuo, Anthony N.
• 通讯作者: Kuo, Anthony N.

Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming.

• DOI: 10.1364/boe.2.001524
• 发表时间: 2011-06-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Larocca F;Chiu SJ;McNabb RP;Kuo AN;Izatt JA;Farsiu S
• 通讯作者: Farsiu S