Intraoperative OCT Guidance of Intraocular Surgery

眼内手术术中OCT指导

• 批准号: 8788030
• 负责人: JOSEPH A IZATT
• 金额: $ 96.96万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8788030
• 关键词: Achievement; Adjuvant; Algorithmic Software; Anatomy; Anterior; Biomedical Engineering; Biomedical Research; Clinic; Clinical Trials; Collaborations; Cornea; Data; Engineering; Evaluation; Eye; Faculty; Feedback; Foundations; Generations; Goals; Health; Image; Imagery; Institutes; Interdisciplinary Study; Laboratories; Leadership; Life; Location; Manufacturer Name; Microscope; Microscopic; Microsurgery; Nursing Faculty; Operating Rooms; Operative Surgical Procedures; Optical Coherence Tomography; Outcome; Patients; Phase; Relative (related person); Research; Retina; Sampling; Speed; Structure; Surgeon; Surgical Instruments; System; Technology; Testing; Time; Tissues; United States National Institutes of Health; Universities; Update; base; clinical research site; data integration; data visualization; design; eye center; functional outcomes; image guided; image processing; improved; instrument; intraoperative imaging; next generation; novel; prototype; research clinical testing; tool; visual feedback

DESCRIPTION (provided by applicant): This Bioengineering Research Partnership proposal brings together a team of experts in ophthalmic imaging and surgery to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon's current stereo microscopic view of ocular structures by bringing optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice, into the operating room. In modern microsurgeries of both the anterior segment and retina, the inability to distinguish delicate, microscopic tissue structures of subtle contrast, or to judge the location of surgical instruments relative to adjacent microstructures, limits achievement of surgical endpoints and patient outcomes. The overall five-year goals of the project are to develop, optimize, apply and document a clinically useful, microscope integrated OCT (MIOCT) technology for ophthalmic surgery that overcomes these limitations. We will also facilitate dissemination of this technology through commercial partnerships. We believe this technology will not only improve outcomes in current surgeries, but will also enable novel ophthalmic and other microsurgeries not possible due to current limitations in visualization. Under previous NIH support (R21EY019411), our leadership team has developed a first-generation OCT- enabled microscope that is specialized for vitreoretinal surgery, and is now undergoing clinical trials at Duke University. This first-generation system delivers unprecedented cross-sectional and three-dimensional views of the retina during surgery. It is now ready for clinical evaluation in a wider range of surgeries, including anterior segment surgery. However, the current prototype lacks real-time feedback for the surgeon, and significant advances are needed in the image acquisition, data visualization and integration, and surgical instrument design, to provide a robust and seamless platform for widespread use by ophthalmic surgeons. Our proposed project is based on multidisciplinary collaborations between biomedical engineers, surgeons and image processing experts devoted to translational advances in imaging for improved outcomes in ophthalmic surgery. The proposed Biomedical Research Partnership comprises academic and clinical faculty from Duke University Biomedical Engineering Department (BME) and Duke Eye Center (DEC), faculty at the Cole Eye Institute (CEI) of the Cleveland Clinic Foundation, and substantial support and collaboration from manufacturers of commercial OCT systems, surgical instruments, and surgical microscopes. Page 1 of 1

描述（由申请人提供）：这项生物工程研究合作伙伴提案汇集了一支在眼科成像和手术方面的专家团队，以在图像引导的手术干预措施中推进最先进的状态。我们试图通过将光学连贯性层析成像（OCT）技术带入手术室实践中已经被广泛接受的眼镜结构（OCT）技术来克服外科医生当前的眼睛结构立体微观观点的局限性。在前部和视网膜的现代显微镜中，无法区分微妙的微观组织结构，或者判断 相对于相邻微观结构的手术工具，限制了手术终点的实现和患者预后。该项目的总体五年目标是开发，优化，应用和记录一种临床上有用的，显微镜综合的OCT（MIOCT）技术，用于克服这些限制的眼科手术。我们还将通过商业合作伙伴关系促进该技术的传播。我们认为，由于目前的可视化局限性，这项技术不仅将改善当前手术中的结果，而且还将使新颖的眼科和其他微生物不可能。 在先前的NIH支持（R21EY019411）的情况下，我们的领导团队开发了一个十月启用显微镜，该显微镜专门用于玻璃体视网膜手术，现在正在杜克大学进行临床试验。该第一代系统在手术过程中提供了视网膜前所未有的横截面和三维视图。现在，它可以在更广泛的手术（包括前部手术）进行更广泛的手术中进行临床评估。但是，目前的原型缺乏外科医生的实时反馈，并且在图像获取，数据可视化和集成以及手术仪器设计中需要显着进步，以提供一个强大而无缝的平台，以通过眼科医生广泛使用。 我们提出的项目是基于生物医学工程师，外科医生和图像处理专家之间的多学科合作，这些专家致力于转化成像进步，以改善眼科手术的结果。提出的生物医学研究合作伙伴关系包括杜克大学生物医学工程系（BME）和杜克眼中中心（DEC）的学术和临床教师，克利夫兰诊所基金会Cole Eye Institute（CEI）的教师，以及来自商业Oct Systems，Oct Systems Systems，Surgical Instruments，Surgical Microsmospes和Surgical Surgical Surgical Microspess的制造商的实质性支持和协作。第1页，共1页