MECHANISMS OF DRUG CRAVING--EXPERIMENTAL STUDIES

描述：(申请人摘要) 这项拟议的研究将探索实验动物的发展 行为行为条件的实验分析模型 药物对渴求发生和变化的测量有影响 寻找、吸毒与相关环境的时间顺序 事件。渴求在吸毒和吸毒期间复发中的突出作用 戒毒使戒毒策略的制定和应用成为可能 控制毒瘾是当前面临的最紧迫的问题之一 药物滥用的治疗和预防。基本行为指标 包括反应模式、一般活动的时间敏感措施 本课程将探讨关卡、社交展示和玩具玩耍与 寻找食物和酒精反应的更常规指标 “力量”的发展，实验室灵长类动物的药物渴求模型。 这些时间敏感的措施将直接在条件下进行评估 与食物有关，首选不含酒精饮料和酒精消费 以及在关联的时间顺序 环境刺激改变，但无论是食物，首选的非酒精 饮料，也没有乙醇。24小时连续测量将 使调查整个范围内的发病和变化成为可能 在基线下的整个昼夜周期中推定的渴求指标 食物、首选的非酒精饮料和乙醇供应时间表 以及在食物有限的情况下，首选不含酒精的 饮料和乙醇的供应。这一比较分析将提供 关于学习和学习中的共性和差异的基本信息 与食物相关的激励过程，首选非酒精类 饮料和乙醇，因为它们涉及到一种有效和 可靠的药物渴求实验室灵长类动物模型。这样的可获得性 动物实验室模型不仅将提供必要的建筑 块，用于更深入和广泛的研究，以增强泛化能力 了解渴望及其与冒险、攻击性和 社会交互，但也将提供一种方法 潜在有效治疗和预防的临床前评估 对一系列可滥用物质的药物渴求的策略。

DESCRIPTION: (Applicant's Abstract) The proposed research will explore the development of a laboratory animal model for the experimental analysis of the conditions under which behavioral measures of the onset of and changes in craving are influenced by drug seeking, drug taking, and the temporal ordering of associated environmental events. The prominent role of craving in drug taking and in relapse during drug abstinence makes the development and application of strategies for the control of drug craving one of the most pressing problems confronting substance abuse treatment and prevention. Basic behavioral indicators including time-sensitive measures of response patterning, general activity levels, social displays, and toy play will be explored in relationship to more conventional indicators of food- and ethanol-seeking response "strength" in the development of a laboratory primate model of drug craving. These time-sensitive measures will be evaluated under conditions directly related to food, preferred non-alcoholic beverage and ethanol consumption as well as under conditions in which the temporal ordering of associated environmental stimuli changes but neither food, the preferred non-alcoholic beverage, nor ethanol is available. Continuous 24-hour measurements will make it possible to investigate onset and change across the range of putative craving indicators throughout the day/night cycle under baseline food, preferred non-alcoholic beverage, and ethanol availability schedules as well as under conditions of limited food, preferred non-alcoholic beverage, and ethanol availability. This comparative analysis will provide basic information on the commonalities and differences in the learning and motivational processes associated with food, preferred non-alcoholic beverage, and ethanol as they relate to the development of a valid and reliable laboratory primate model of drug craving. The availability of such an animal laboratory model will not only provide the essential building blocks for more intensive and extensive research to enhance generalizable knowledge about craving and its relationship to risk taking, aggression, and social interactions but will as well provide a methodology for the preclinical evaluation of potentially effective treatment and prevention strategies for drug craving over a range of abusable substances.