ENVIRONMENTAL/BEHAVIORAL INTERACTIONS AND DRUG TAKING

这是一个持续支持ADAMHA研究的请求 科学家奖。 长期目标和具体目标 建议的研究重点是发展可推广的知识 与寻求毒品的环境和行为决定因素有关 和吸毒，因为这些过程影响到公共卫生问题 与药物依赖和滥用有关。 具体而言，拟议的调查将强调 实验研究的加强，歧视， 药物滥用的生理依赖性 实验室灵长类动物，特别是最常被滥用的 镇静剂/催眠剂/抗焦虑剂和兴奋剂（例如，苯并二氮杂， 安非他明、可卡因）。 静脉和口服途径 将研究给药，并将研究作用的分子机制。 研究了 还将进行调查，以确定急性 以及这些药物对感觉和运动功能的慢性影响， 单独滥用和混合滥用，以便制定适当的 实验室灵长类动物行为毒性数据库。 这些研究将 涉及动物心理物理学方法的应用和扩展， 药物对听觉和视觉阈值、反应 时间和元音辨别功能。 还将开展研究，探讨各种决定因素， 在人类志愿者中寻求药物和服用药物的后果 一个持续编程的住宅实验室的背景下， 小规模社会系统的实验分析 强调受虐待者的动机和表现影响 在这种情况下的物质（例如大麻）。 这几个方面之间的相互关系 科学探究和拟议研究的长期目标 加强与药物依赖可能性有关的知识基础， 滥用责任应在统一的概念范围内理解， 一个环境/生物行为模型的框架， 多个互动层面的调查工作集中在 寻求毒品和吸毒是公共卫生的重要方面 关心

This is a request for continued support of an ADAMHA Research Scientist Award. The long-term objectives and specific aims of the proposed research focus upon the development of generalizable knowledge relevant to the environmental and behavioral determinants of drug-seeking and drug-taking as these processes bear upon public health concerns related to drug dependence and abuse. More specifically, the proposed investigations will emphasize experimental studies of the reinforcing, discriminative, and physiological dependence-producing properties of drugs of abuse in laboratory primates with particular reference to the most commonly abused sedative/hypnotic/anxiolytic and stimulant agents (e.g., benzodiazepines, amphetamines, cocaine). Both intravenous and oral routes of administration will be studied and molecular mechanisms of action will be investigated. Investigations will also be undertaken to determine the acute and chronic effects upon sensory and motor functions of such drugs of abuse both singly and in combination so as to develop an appropriate behavioral toxicity data base in laboratory primates. These studies will involve applications and extensions of animal psychophysical methods for assessment of drug effects upon auditory and visual thresholds, reaction times, and vowel discrimination functions. Studies will also be undertaken to explore the determinants and consequences of drug-seeking and drug-taking in human volunteers within the context of a continuously programmed residential laboratory for the experimental analysis of small scale social systems with particular emphasis upon the motivational and performance effects of abused substances (e.g. marijuana) under such conditions. The interrelationships between these several aspects of scientific inquiry and the longterm objectives of the proposed research to enhance the knowledge base relevant to drug dependence potential and abuse liability is to be understood within the unifying conceptual framework of an environmental/biobehavioral model for integrating the multiple interacting levels of investigative effort focused upon drug-seeking and drug-taking as critical aspects of public health concern.