FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX

描述：拟议实验的长期目标是 确定满足以下条件的基本处理原则和策略 复数的皮质变换和表示 听起来。我们在此建议探讨 成年食肉动物(猫科猫科动物)的初级听觉皮质 具体提到它的层状组织。一个主要的前提是 人工智能包含了广泛的神经元反应特性 丘脑-皮质主要输入层和具有类似 功能属性通常聚集在人工智能的子区域中。 非均匀空间分布之间的相互关系 主要的功能属性和结构组织 将使用电生理学和电生理学相结合的方法研究听觉皮质 神经解剖学方法。通过将功能属性和 神经元在大脑皮层组织方面的分布， 大脑皮层特征的一般原理 表示和变换可以评估为简单和 复杂的声音。 第一个目标是定义特定于层的功能组织 AI代表简单和复杂的声音。据推测，单身汉 大脑皮层III、IV和V层的神经元将显示不同 在他们对纯音的接受场属性中，光谱 宽带刺激的包络特征，以及对于重复或 顺序刺激。感受野的层状分布 纯音刺激的属性将从单音获得 参考多个单位映射的单位。 第二个目标是识别丘脑的输入模式以 人工智能中的功能区。据推测，丘脑 人工智能中功能不同的子区域的输入模式不同。至 探索丘脑皮质投射在功能上的区别 部分等频轴，红色和绿色荧光乳胶 微球将在体内的两个不同位置注射 同一频段作为逆行神经元的示踪剂。 第三个目标是将皮质内连接与功能联系联系起来 人工智能的子区域。据推测，斑片状的皮质 投影与补丁泛函的某些方面有关 组织。这些实验将提供证据，证明一些 具有相似光谱、强度或时间的功能亚区 处理能力显示出更大的皮质内连接 具有明显不同功能特性的亚区。去探索 人工智能内部的内在投射模式，小微压 注射生物素化葡聚糖胺(BDA)将应用于 顺行末端标签在人工智能中的分布将是 参照多个单位图进行评估。

Description: The long-term goal of the proposed experiments is to identify the fundamental processing principles and strategies that underlie the cortical transformations and representations of complex sounds. We propose here to explore the functional organization of the primary auditory cortex, AI, in adult carnivores (Felis catus) with specific reference to its laminar organization. A main premise is that AI contains wide ranges of neuronal response properties in the main thalamo-cortical input layers and that neurons with similar functional properties are typically clustered in subregions of AI. Inter-relations between non-homogeneous spatial distributions of functional properties and structural organizations of the primary auditory cortex will be studied using combined electrophysiological and neuroanatomical methods. By relating the functional properties and distributions of neurons to aspects of cortical organization, general principles underlying the characteristics of cortical representations and transformations can be assessed for simple and complex sounds. The first aim is to define layer-specific functional organizations of AI for simple and complex sounds. It is hypothesized that single neurons in cortical layers III, IV, and V will show differences in their receptive field attributes for pure tones, spectral envelope features of broad-band stimuli, and for repetitive or sequential stimuli. The laminar distribution of receptive field properties for pure tone stimulation will be obtained from single units with reference to multiple unit maps. The second aim is to identify the thalamic input pattern to functional subregions in AI. It is hypothesized that the thalamic input patterns to functionally distinct subregions in AI differ. To explore the thalamocortical projections to functionally distinct portions of the isofrequency axis, red and green fluorescent latex microspheres will be injected at two different locations within the same frequency band to serve as retrograde neuronal tracers. The third aim is to relate intracortical connections to functional subregions of AI. It is hypothesized that patchy corticocortical projections are related to some aspects of the patchy functional organizations. These experiments will provide evidence whether some functional subregions with similar spectral, intensity, or temporal processing capacities show greater intracortical connectivity than subregions with distinctly different functional properties. To explore the intrinsic projection patterns within AI, small micropressure injections of biotinylated dextran amine (BDA) will be applied and the distribution of anterograde terminal label in AI will be assessed with reference to multiple unit maps.