FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX

描述：(改编自调查人员摘要)的长期目标 建议的实验是为了确定基本的加工原理 以及作为大脑皮层转换和表示的基础的策略 复杂的声音。作者建议对职能组织进行探索 成年食肉动物(猫科猫科)初级听觉皮质AI的变化 具体提到它的层状组织。一个主要的前提是人工智能 包含广泛的神经元响应特性，主要 丘脑-皮质输入层和具有相似功能神经元 属性通常聚集在人工智能的子区域中。两者之间的相互关系 功能特性和结构的非均匀空间分布 初级听觉皮质的组织将使用组合的 电生理和神经解剖学方法。通过关联功能 神经元在大脑皮层组织方面的特性和分布， 大脑皮层表征特征的一般原则 可以对简单和复杂的声音进行转换。 第一个目标是为以下对象定义特定于层的AI功能组织 简单和复杂的声音。假设大脑皮层中的单个神经元 第三层、第四层和第五层在它们的感受野中表现出不同 纯音的属性，宽带刺激的频谱包络特征， 以及用于重复或顺序刺激。感受器的层状分布 纯音和波纹刺激的场属性将通过以下方式获得 参照多个单位地图的单个单位。 第二个目标是确定丘脑的功能输入模式 人工智能中的子区域。据推测，丘脑的输入模式 人工智能中功能不同的亚区不同。探索丘脑皮质 投射到等频轴的功能不同部分，红色和 绿色荧光乳胶微球将在两个不同的位置注射 在同一频段内用作逆行神经元示踪剂。 第三个目标是将皮质内连接与功能亚区联系起来 人工智能。假设大脑皮层的斑片投射与 一些零散的职能组织。这些实验将 提供证据是否某些功能亚区具有相似的光谱， 强度，或时间处理能力显示出更大的皮质内 连通性比具有明显不同功能特性的亚区更大。 第四个目标是确定神经功能之间的相互作用 子区域。具体地说，作者将衡量相关程度 以及在具有相似带宽或双耳的区域中的响应之间的同步 属性。

DESCRIPTION: (Adapted from the Investigator's Abstract) The long-term goal of the proposed experiments is to identify the fundamental processing principles and strategies that underlie the cortical transformations and representations of complex sounds. The authors propose to explore the functional organization of the primary auditory cortex, AI, in adult carnivores (Felis catus) with specific reference to its laminar organization. A main premise is that AI contains wide ranges of neuronal response properties in the main thalamo-cortical input layers and that neurons with similar functional properties are typically clustered in subregions of AI. Inter-relations between non-homogeneous spatial distributions of functional properties and structural organizations of the primary auditory cortex will be studied using combined electrophysiological and neuroanatomical methods. By relating the functional properties and distributions of neuron to aspects of cortical organization, general principles underlying the characteristics of cortical representations and transformations can be assessed for simple and complex sounds. The first aim is to define layer-specific functional organizations of AI for simple and complex sounds. It is hypothesized that single neurons in cortical layers, III, IV, and V will show differences in their receptive field attributes for pure tones, spectral envelope features of broad-band stimuli, and for repetitive or sequential stimuli. The laminar distribution of receptive field properties for pure tone and ripple stimulation will be obtained from single units with reference to multiple unit maps. The second aim is to identify the thalamic input pattern to functional subregions in AI. It is hypothesized that the thalamic input patterns to functionally distinct subregions in AI differ. To explore the thalamocortical projections to functionally distinct portions of the isofrequency axis, red and green flourescent latex micropheres will be injected at two different locations within the same frequency band to serve as retrograde neuronal tracers. The third aim is to relate intracortical connections to functional subregions of AI. It is hypothesized that patchy corticocortical projections are related to some aspects of the patchy functional organizations. These experiments will provide evidence whether some functional subregions with similar spectral, intensity, or temporal processing capacities show greater intracortical connectivity than subregions with distinctly different functional properties. The forth aim is to determine the neural interactions between functional subregions. Specifically, the authors will measure the degree of correlation and synchrony between the responses in regions of similar bandwidth or binaural properties.