CODING IN AUDITORY NEURONS--EFFECTS OF AMINO ACIDS

听觉神经元的编码——氨基酸的作用

• 批准号: 2733627
• 负责人: Donald M. Caspary
• 金额: $ 17.28万
• 依托单位: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2733627
• 关键词: GABA receptor; aging; auditory nuclei; chinchilla; gamma aminobutyrate; inferior colliculus; iontophoresis therapy; laboratory rat; neural transmission; neurons; neuropharmacology

DESCRIPTION: Studies completed in this laboratory during the past several years have contributed to our understanding of two closely related questions in auditory research: 1) How do inhibitory amino acids function within known brainstem auditory circuits to encode acoustic information? 2) What is the impact of aging on inhibitory amino acid neurotransmission in the auditory brainstem? Studies of this nature have made significant inroads into the nature of presbycusis, a major disorder among the aged and may lead to pharmacological treatment strategies for age-related hearing loss. In vivo iontophoretic and in vitro studies in cochlear nucleus (CN) and inferior colliculus (IC) have revealed that inhibitory amino acid neurotransmitters are critically involved in the control of dynamic range, echo suppression and detection of signal in noise. Recent studies from this laboratory suggest that circuits within the CN and IC undergo age-related changes associated with inhibitory neurotransmission. The current proposal will extend this strong foundation of work by carrying out the following proposed studies: 1) microiontophoresis to examine the role of the inhibitory amino acid GABA in shaping responses to amplitude modulated sinusoids in the IC; 2) neurochemical techniques to further characterize age-related changes in the molecular nature of the GABAA receptor; and 3) single unit physiology to examine age-related changes in the response properties of DCN fusiform cells.

描述：过去几个实验室完成的研究 多年有助于我们理解两个密切相关的问题 在听觉研究中：1）抑制性氨基酸如何在 已知的脑干听觉电路编码声学信息？ 2）什么 是衰老对抑制性氨基酸神经传递的影响 听觉脑干？ 对这种性质的研究已经大大侵犯 进入长老会的本质，这是老年人中的主要疾病，可能会导致 到与年龄相关的听力损失的药理治疗策略。 人工耳蜗核（CN）和 下丘（IC）表明抑制性氨基酸 神经递质与动态范围的控制非常重要， 回声抑制和检测噪声中的信号。 最近的研究 实验室建议CN和IC内的电路与年龄有关 与抑制性神经传递相关的变化。 当前的建议 通过执行以下内容，将扩大这一强大的工作基础 拟议的研究：1）微观噬菌体检查 抑制性氨基酸GABA在对幅度调制的响应中 IC中的正弦； 2）神经化学技术进一步表征 GABAA受体的分子性质与年龄相关的变化； 3） 单位生理学以检查与年龄相关的反应变化 DCN梭形细胞的性质。