FIBROMYALGIA, DEPRESSION AND MYOFASCIAL TMD

纤维肌痛、抑郁症和肌筋膜 TMD

• 批准号: 2843420
• 负责人: KAREN G. RAPHAEL
• 金额: $ 48.53万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2843420
• 关键词: clinical research; comorbidity; disease /disorder etiology; family genetics; female; fibromyalgia; human subject; interview; major depression; mental health epidemiology; statistics /biometry; temporomandibular joint syndrome

DESCRIPTION (taken from the application): The well-established comorbidity of fibromyalgia (FMS) and major depression (MDD) has motivated speculations about the direction of the relationship. Three principal hypotheses to be tested here are: (l)that FMS is a variant of depression; (2) that MDD in FMS sufferers is a reaction to FMS; and (3) that high rates of MDD in FMS patients are an artifact of studying treatment-seekers. The proposed study's first aim is to support one and refute other hypotheses, by conducting a family study. Community women meeting criteria for FMS (n= 120) will be stratified so that half (n=60) have a lifetime history of MDD. Demographically-matched non-FMS controls (n= 120) from the same sampling frame will also be stratified on MDD status. Direct psychiatric interviews and physical examinations will be conducted with probands and all their available adult first degree relatives. To support the first hypothesis, familial MDD rates should be elevated in FMS probands, even among probands with no personal depression histories; to support the second, probands with FMS and MDD should have low familial depression rates, as their depression should be more likely reactive to FMS; to support the last, familial MDD should be elevated in probands with MDD histories themselves, regardless of FMS status. A second aim, prompted by the comorbidity of FMS and myofascial temporomandibular disorder (M/TMD), is test (1) whether M/TMD is a regional manifestation of FMS or (2) whether M/TMD comorbid with FMS is different from M/TMD expressed as a regional disorder. To accomplish this aim, we will first reconfirm that FMS is familial, utilizing data gathered to satisfy the first aim. Second, we will reconstitute the groups from Aim 1, according to both FMS and M/TMD status. Rates of familial M/TMD in FMS and control probands, broken down by proband M/TMD status, will be examined. If M/TMD is found in the family of FMS probands, regardless of proband M/TMD status, this will support the first hypothesis. If only FMS probands have familial M/TMD but M/TMD probands do not, this will support the 2nd hypothesis and indicate that the two disorders are provoked through different pathogenic processes.

描述（取自应用程序）： 纤维肌痛（FMS）和重度抑郁症的明确共病 (MDD)引发了人们对这段关系走向的猜测。三 这里要检验的主要假设是：（1）FMS是一种变体， 抑郁症;（2）FMS患者的MDD是对FMS的反应;（3） FMS患者中MDD的高发生率是研究 寻求治疗的人这项研究的第一个目的是支持一个观点， 其他假设，通过进行家庭研究。社区妇女会议 将对FMS标准（n= 120）进行分层，以便一半（n=60）具有 MDD的终身史。人口统计学匹配的非FMS对照组（n= 120）， 同样的采样框架也将根据MDD状态进行分层。直接 将进行精神病面谈和身体检查， 先证者和他们所有的成年一级亲属。支持 第一个假设，家族性MDD率应在FMS先证者中升高，即使 在没有个人抑郁史的先证者中;为了支持第二个， FMS和MDD的先证者应该有较低的家族性抑郁率，因为他们 抑郁症应该更容易对FMS反应;为了支持最后一个家族性的 MDD在有MDD病史的先证者中应该升高，无论 FMS状态。第二个目标，由FMS和肌筋膜的并发症引起， 颞下颌关节紊乱病（M/TMD），是测试（1）M/TMD是否是一个区域性 （2）M/TMD是否与FMS共病， M/TMD表现为区域性疾病。为了实现这一目标，我们将首先 再次确认FMS是家族性的，利用收集的数据来满足第一个 瞄准其次，我们将根据两个FMS， M/TMD状态。FMS和对照先证者中家族性M/TMD的发生率， 根据先证者M/TMD状态，将进行检查。如果在家族中发现M/TMD 的FMS先证者，无论先证者M/TMD状态如何，这将支持 第一个假设如果只有FMS先证者有家族性M/TMD，但M/TMD先证者 这将支持第二个假设，并表明两个 疾病是通过不同的致病过程引起的。