Understanding sperm motion at surfaces

了解精子在表面的运动

• 批准号: DP190100343
• 负责人: Dr Reza Nosrati
• 金额: $ 32.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-05-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100343
• 关键词: Understanding; sperm; motion; surfaces

This project aims to reveal the biophysics of sperm motion at surfaces, using 3D imaging, advanced mathematical modelling, and microfluidics. This interdisciplinary project expects to generate new knowledge of sperm flagellar activity, using an innovative microfluidic approach to measure full dynamics of sperm motion in 3D and compare experimental observations with computational results. The project is expected to reveal the intraflagellar mechanisms that trigger the switch between 3D and 2D flagellar waveforms near surfaces. This should provide significant benefits, such as important insights into the biophysics of mammalian reproduction and the origin of flagellar motility in eukaryotes.

该项目旨在利用3D成像、先进的数学建模和微流体技术揭示精子在表面运动的生物物理学。这个跨学科的项目预计将产生精子鞭毛活动的新知识，使用创新的微流体方法来测量3D精子运动的完整动态，并将实验观察结果与计算结果进行比较。该项目有望揭示触发表面附近3D和2D鞭毛波形之间切换的鞭毛内机制。这应该提供显着的好处，如重要的见解哺乳动物生殖的生物物理学和真核生物中鞭毛运动的起源。