Fallopian tube on-a-chip for understanding mammalian reproduction

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This project aims to reveal the fundamental physics and biology of mammalian reproduction by engineering the first comprehensive 3D culture model of the fallopian tube. The project expects to generate significant new knowledge about the exact role of the fallopian tube anatomy and physiology on the formation and function of epithelial tissue, using innovative approaches to simultaneously measure the full dynamics of epithelial cell activity and sperm motion. The expected outcome of the project is to reveal the cooperative role of sperm, egg and epithelial tissue on fertilisation. This should provide significant benefits, such as important biophysical insights into mammalian reproduction and new research tools to replace animal models.