Fallopian tube on-a-chip for understanding mammalian reproduction

用于了解哺乳动物生殖的输卵管芯片

• 批准号: DE230100400
• 负责人: Dr Reza Nosrati
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2023-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100400
• 关键词: Fallopian; tube; chip; understanding; mammalian

This project aims to reveal the fundamental physics and biology of mammalian reproduction by engineering the first comprehensive 3D culture model of the fallopian tube. The project expects to generate significant new knowledge about the exact role of the fallopian tube anatomy and physiology on the formation and function of epithelial tissue, using innovative approaches to simultaneously measure the full dynamics of epithelial cell activity and sperm motion. The expected outcome of the project is to reveal the cooperative role of sperm, egg and epithelial tissue on fertilisation. This should provide significant benefits, such as important biophysical insights into mammalian reproduction and new research tools to replace animal models.

该项目旨在通过构建第一个全面的输卵管3D培养模型来揭示哺乳动物生殖的基本物理学和生物学。该项目预计将产生关于输卵管解剖学和生理学对上皮组织形成和功能的确切作用的重要新知识，使用创新方法同时测量上皮细胞活动和精子运动的完整动态。该项目的预期成果是揭示精子、卵子和上皮组织在受精过程中的协同作用。这将带来重大的好处，例如对哺乳动物生殖的重要生物物理见解和取代动物模型的新研究工具。