THE SLEEP HEART HEALTH STUDY

睡眠心脏健康研究(SHHS)始于1994年，是一项关于睡眠障碍呼吸(SDB)对心血管后果的多中心队列研究。这项研究的主要目的是评估SDB作为不良心血管结局的危险因素，包括CHD事件、中风和高血压，以及随着年龄的增长血压加速上升。SHHS方案在正在进行的心血管和其他疾病队列研究中增加了对SDB的评估，包括Framingham子孙和OMNI队列研究，社区动脉粥样硬化风险(ARIC)研究的黑格斯敦和明尼阿波利斯/圣保罗研究站点，心血管健康研究(CHS)的黑格斯敦、萨克拉门托和匹兹堡站点，南达科他州、俄克拉何马州和亚利桑那州的强心脏研究站点，以及图森的呼吸系统疾病和纽约高血压的队列研究。在最初的四年中(1994-1998年)，SHHS成功地启动了，在家中从6440名参与者那里获得了全面和高质量的多导睡眠图(PSG)数据，并在中央阅读中心进行了评分。SHHS队列包括3039名男性和3401名女性，年龄在40岁或以上，其中8.2%是非洲裔美国人，9.6%是美国印第安人，1.3%是亚洲人，4.2%是西班牙裔。除了PSG，数据收集还包括鼾声、嗜睡和生活质量(QOL)。所有队列的结果评估方案都已到位，第二次SHHS考试现在正在进行中。初步的横断面研究结果表明，SDB很常见，并与高血压和自我报告的心血管疾病(CVD)有关。这项申请需要五年的额外支持才能继续实施SHHS。需要进一步的后续研究，才能有足够的力量来检验主要的SHHS假说。此外，在第7至第9年，将重复PSG，以进一步描述参与者的SDB特征，并描述SDB的自然历史。在最初的五年中，SHHS已经表明，可以在社区中进行关于睡眠、SDB和疾病风险的大规模研究。对SHHS队列的后续研究将提供描述SDB心血管后果所需的数据，以及其自然病史。这份申请描述了卫生与公众服务部现场中心继续收集数据和跟进的计划。目前正在提交继续设立阅读中心的单独申请，并将选择一个新的协调中心。

The Sleep Heart Health Study (SHHS) was started in 1994 as a multicenter cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). The study's principal aims are to assess SDB as a risk factor for adverse cardiovascular outcomes, including incident CHD events, stroke, and hypertension, and accelerated increase in blood pressure with age. The SHHS protocol added an assessment of SDB to ongoing cohort studies of cardiovascular and other diseases, including the Framingham Offspring and Omni cohorts, the Hagerstown and Minneapolis/St. Paul sites of the Atherosclerosis Risk in Communities (ARIC) Study, the Hagerstown, Sacramento, and Pittsburgh sites of the Cardiovascular Health Study (CHS), the Strong Heart Study sites in South Dakota, Oklahoma, and Arizona, and cohort studies of respiratory disease in Tucson and of hypertension in New York. During its first four years (1994-1998), the SHHS was successfully started with full and high quality polysomnography (PSG) data obtained in the home from 6,440 participants and scored at the Central Reading Center. The SHHS cohort includes 3,039 men and 3,401 women 40 years of age or more, of whom 8.2 percent are African American, 9.6 percent are American Indian, 1.3 percent are Asian, and 4.2 percent are Hispanic. In addition to PSG, data collection covered snoring and sleepiness and quality of life (QOL). Outcome assessment protocols are in place for all cohorts and the second SHHS exam is now in progress. Initial cross-sectional findings show that SDB is common and associated with hypertension and self-reported cardiovascular disease (CVD). This application requests five years of additional support to continue the SHHS. Further follow-up is needed for sufficient power to test the primary SHHS hypotheses. Additionally, in Years 7-9, PSG will be repeated to further characterize SDB in the participants and to describe the natural history of SDB. During the first five years, the SHHS has shown that large-scale research on sleep, SDB, and disease risk can be conducted in the community. Follow-up of the SHHS cohort will provide the data needed to characterize the cardiovascular consequences of SDB, along with its natural history. This application describes plans for continued data collection and follow-up by the SHHS Field Centers. A separate application for continuation of the Reading Center is being submitted and a new Coordinating Center will be selected.