SLEEP DISORDERED BREATHING, METABOLIC SYNDROME, AND VASCULAR FUNCTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 [from CRISP网站（编辑）] 胰岛素抵抗和代谢综合征与血管内皮功能障碍和动脉粥样硬化有共同的危险因素和致病机制。睡眠呼吸障碍（SDB）可能以复杂的方式与这个引起疾病的区域相关，既作为结果（通过肥胖），也作为原因（通过低氧血症，氧化应激和交感神经超负荷）。本研究的主要目的是在威斯康星州睡眠队列（WSC）研究（SPID 8813）的参与者样本中研究SDB与代谢综合征和血管功能障碍发生率之间的纵向相关性，该研究是一组在过去15年中重复进行完整睡眠研究的中年个体，每个参与者最多4次，间隔4年。 本研究将招募600例在WSC中接受至少2次访视的受试者。 该组包括a）约150例偶发代谢综合征病例，和B）约450-470名队列成员的随机样本。这些参与者将接受血管功能的非侵入性测量，包括：（1）肱动脉反应性;（2）脑动脉对高碳酸血症的反应性;和（3）视网膜小动脉/小静脉比率。此外，我们将测量缺氧应激（VEGF）、氧化应激（尿异前列腺素）、交感神经和下丘脑-垂体-肾上腺轴功能（心率变异性、尿去甲肾上腺素、尿皮质醇）的标志物。该研究将检验以下假设：最近或过去的SDB可预测代谢综合征的发生，并与胰岛素抵抗程度（HOMA-IR）和血管或内皮功能障碍有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [from CRISP website (edited)] Insulin resistance and the metabolic syndrome share risk factors and disease-causing mechanisms with vascular endothelial dysfunction and atherosclerosis. Sleep disordered breathing (SDB) might be associated with this diesease-causing area in complex ways, both as a result (via obesity) and as a cause (via hypoxemia, oxidative stress, and sympathetic overload). The primary objective of this study is to study the longitudinal association between SDB and the incidence of the metabolic syndrome and vascular dysfunction in a sample of participants in the Wisconsin Sleep Cohort (WSC) Study (SPID 8813), a group of middle-age individuals who have undergone repeated full sleep studies over the last 15 years, up to four in each participants, four years apart. A total of 600 participants with at least 2 visits in the WSC will be recruited into the study. This group includes a) about 150 cases of incident metabolic syndrome, and b) a random sample of about 450-470 members of the cohort. These participants will undergo non-invasive measures of vascular function including: (1) brachial artery reactivity; (2) cerebral artery responsiveness to hypercapnia; and (3) retinal arteriolar/venular ratio. In addition, we will measure markers of hypoxic stress (VEGF), oxidative stress (urinary isoprostane), and sympathetic and hypothalamic-pituitary-adrenal axis function (heart rate variability, urinary norepinephrine, urinary cortisol). The proposed study will test the hypothesis that recent or past SDB predicts incident metabolic syndrome and is related to the degree of insulin resistance (HOMA-IR), and vascular or endothelial dysfunction.