SLEEP DISORDERED BREATHING, METABOLIC SYNDROME, AND VASCULAR FUNCTION

睡眠呼吸障碍、代谢综合征和血管功能

• 批准号: 7607517
• 负责人: F. JAVIER NIETO
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607517
• 关键词: Area; Atherosclerosis; Blood Vessels; Cohort Studies; Complex; Computer Retrieval of Information on Scientific Projects Database; Disease; Functional disorder; Funding; Grant; Heart Rate; Hydrocortisone; Hypercapnia; Hypoxemia; Hypoxia; Incidence; Individual; Institution; Insulin Resistance; Invasive; Isoprostanes; Longitudinal Studies; Measures; Metabolic syndrome; Norepinephrine; Obesity; Oxidative Stress; Participant; Recruitment Activity; Research; Research Personnel; Resources; Retinal; Risk Factors; Sampling; Sleep; Sleep Apnea Syndromes; Source; Stress; Testing; United States National Institutes of Health; Vascular Endothelial Growth Factors; Visit; Wisconsin; brachial artery; cerebral artery; cohort; hypothalamic-pituitary-adrenal axis; member; middle age; urinary; vascular endothelial dysfunction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [from CRISP website (edited)] Insulin resistance and the metabolic syndrome share risk factors and disease-causing mechanisms with vascular endothelial dysfunction and atherosclerosis. Sleep disordered breathing (SDB) might be associated with this diesease-causing area in complex ways, both as a result (via obesity) and as a cause (via hypoxemia, oxidative stress, and sympathetic overload). The primary objective of this study is to study the longitudinal association between SDB and the incidence of the metabolic syndrome and vascular dysfunction in a sample of participants in the Wisconsin Sleep Cohort (WSC) Study (SPID 8813), a group of middle-age individuals who have undergone repeated full sleep studies over the last 15 years, up to four in each participants, four years apart. A total of 600 participants with at least 2 visits in the WSC will be recruited into the study. This group includes a) about 150 cases of incident metabolic syndrome, and b) a random sample of about 450-470 members of the cohort. These participants will undergo non-invasive measures of vascular function including: (1) brachial artery reactivity; (2) cerebral artery responsiveness to hypercapnia; and (3) retinal arteriolar/venular ratio. In addition, we will measure markers of hypoxic stress (VEGF), oxidative stress (urinary isoprostane), and sympathetic and hypothalamic-pituitary-adrenal axis function (heart rate variability, urinary norepinephrine, urinary cortisol). The proposed study will test the hypothesis that recent or past SDB predicts incident metabolic syndrome and is related to the degree of insulin resistance (HOMA-IR), and vascular or endothelial dysfunction.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 [来自 CRISP 网站（编辑）] 胰岛素抵抗和代谢综合征与血管内皮功能障碍和动脉粥样硬化有共同的危险因素和致病机制。睡眠呼吸障碍 (SDB) 可能以复杂的方式与这一致病区域相关，既可以作为结果（通过肥胖），也可以作为原因（通过低氧血症、氧化应激和交感神经超载）。本研究的主要目的是研究威斯康星州睡眠队列 (WSC) 研究 (SPID 8813) 参与者样本中 SDB 与代谢综合征和血管功能障碍发生率之间的纵向关联，该样本是一组在过去 15 年中重复进行完全睡眠研究的中年个体，每个参与者最多 4 人，间隔四年。 该研究将招募总共 600 名至少参加过 WSC 2 次的参与者。 该组包括 a) 约 150 例代谢综合征病例，以及 b) 约 450-470 名队列成员的随机样本。这些参与者将接受血管功能的非侵入性测量，包括：（1）肱动脉反应性； (2)脑动脉对高碳酸血症的反应性； (3)视网膜小动脉/小静脉比率。此外，我们还将测量缺氧应激 (VEGF)、氧化应激（尿异前列烷）以及交感神经和下丘脑-垂体-肾上腺轴功能（心率变异性、尿去甲肾上腺素、尿皮质醇）的标志物。拟议的研究将检验以下假设：最近或过去的 SDB 可以预测代谢综合征的发生，并且与胰岛素抵抗程度 (HOMA-IR) 以及血管或内皮功能障碍有关。