SLEEP DISORDERED BREATHING, METABOLIC SYNDROME, AND VASCULAR FUNCTION

睡眠呼吸障碍、代谢综合征和血管功能

• 批准号: 7375521
• 负责人: F. JAVIER NIETO
• 金额: $ 5.74万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375521
• 关键词: SLEEP; DISORDERED; BREATHING; METABOLIC; SYNDROME

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [from CRISP website (edited)] Insulin resistance and the metabolic syndrome share risk factors and disease-causing mechanisms with vascular endothelial dysfunction and atherosclerosis. Sleep disordered breathing (SDB) might be associated with this diesease-causing area in complex ways, both as a result (via obesity) and as a cause (via hypoxemia, oxidative stress, and sympathetic overload). The primary objective of this study is to study the longitudinal association between SDB and the incidence of the metabolic syndrome and vascular dysfunction in a sample of participants in the Wisconsin Sleep Cohort (WSC) Study (SPID 8813), a group of middle-age individuals who have undergone repeated full sleep studies over the last 15 years, up to four in each participants, four years apart. A total of 600 participants with at least 2 visits in the WSC will be recruited into the study. This group includes a) about 150 cases of incident metabolic syndrome, and b) a random sample of about 450-470 members of the cohort. These participants will undergo non-invasive measures of vascular function including: (1) brachial artery reactivity; (2) cerebral artery responsiveness to hypercapnia; and (3) retinal arteriolar/venular ratio. In addition, we will measure markers of hypoxic stress (VEGF), oxidative stress (urinary isoprostane), and sympathetic and hypothalamic-pituitary-adrenal axis function (heart rate variability, urinary norepinephrine, urinary cortisol). The proposed study will test the hypothesis that recent or past SDB predicts incident metabolic syndrome and is related to the degree of insulin resistance (HOMA-IR), and vascular or endothelial dysfunction.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。[来自CRISP网站(编辑)]胰岛素抵抗和代谢综合征与血管内皮功能障碍和动脉粥样硬化具有共同的风险因素和致病机制。睡眠呼吸障碍(SDB)可能以复杂的方式与这一致病区域相关，既是结果(通过肥胖)，也是原因(通过低氧血症、氧化应激和交感神经过载)。这项研究的主要目的是在威斯康星州睡眠队列(WSC)研究(SPID 8813)的参与者样本中研究SDB与代谢综合征和血管功能障碍的发生率之间的纵向关联。WSC研究是一组中年个体，在过去15年中反复进行全睡眠研究，每个参与者最多四次，间隔四年。这项研究将招募总共600名至少有两次访问的WSC参与者。这一组包括a)大约150例偶发代谢综合征病例，以及b)队列中大约450-470名成员的随机样本。这些参与者将接受血管功能的非侵入性测量，包括：(1)臂动脉反应性；(2)脑动脉对高碳酸血症的反应性；(3)视网膜小动脉/小静脉比率。此外，我们还将测量低氧应激(VEGF)、氧化应激(尿异前列腺素)和交感神经和下丘脑-垂体-肾上腺轴功能(心率变异性、尿去甲肾上腺素、尿皮质醇)的标志物。这项拟议的研究将检验这样一种假设，即最近或过去的SDB预测发生的代谢综合征，并与胰岛素抵抗程度(HOMA-IR)和血管或内皮功能障碍有关。