ESTROGEN AND PRIMATE BRAIN CELLS REGULATING GONADOTROPIN

描述(改编自《调查员摘要》)：本申请 将检验这一假设，除了它对 神经递质的产生和受体，雌激素影响促性腺激素 灵长类动物通过调节突触之间的连接而分泌 GnRH递送系统的要素。调查员提出，通过 排卵前促性腺激素高峰时间、排卵前促性腺激素释放量与排卵前促性腺激素释放量 GnRH神经元上的刺激性和抑制性突触比 在月经周期的其他时间。为了检验这一假设， 研究人员将确定GnRH的突触连接和活性 雌激素调控下猴脑内神经元的变化 促性腺激素。在项目期间，调查员将研究：1) 实验刺激的正反馈由给药引起 雌二醇：2)正常卵巢中的负反馈和正反馈 周期；3)正常男性的反馈；4)卵巢切除或 没有激素替代；5)自然发生的更年期。三 主要的抑制性和三大刺激性神经递质系统 在本项目中进行了研究。

DESCRIPTION (Adapted from the Investigator's Abstract): This application will test the hypothesis that, in addition to its effects on neurotransmitter production and receptors, estrogen affects gonadotropin secretion in primates by regulating the synaptic connections between elements of the GnRH delivery system. The investigator proposes that by the time of the preovulatory gonadotropin surge, the ratio of the number of stimulatory and inhibitory synapses is higher on GnRH neurons than at any other time during the menstrual cycle. To test this hypothesis, the investigator will determine the synaptic connection and activity of GnRH neurons in the monkey brain during estrogen-regulated control of gonadotropins. During the project period, the investigator will study: 1) experimentally stimulated positive feedback induced by administered estradiol: 2) negative and positive feedback during the normal ovarian cycle; 3) feedback in normal males; 4) effects of ovariectomy with or without hormone replacement; and 5) naturally occurring menopause. Three major inhibitory and three major stimulator neurotransmitter systems will be studied in this project.