ESTROGEN AND PRIMATE BRAIN CELLS REGULATING GONADOTROPIN

描述（改编自研究者摘要）：本申请 将测试的假设，除了它的影响， 神经递质的产生和受体，雌激素影响促性腺激素 通过调节突触之间的连接， GnRH传递系统的组成部分。 调查人员建议， 排卵前促性腺激素峰的时间， 刺激性和抑制性突触在GnRH神经元上比在任何 月经周期中的其他时间。 为了验证这一假设， 研究者将确定GnRH的突触连接和活性 在雌激素调节的控制过程中， 促性腺激素 在项目期间，研究者将研究：1） 实验刺激的正反馈诱导的管理 雌二醇：2）正常卵巢期的负反馈和正反馈 周期; 3）正常男性的反馈; 4）卵巢切除术或 没有激素替代;和5）自然发生的更年期。 三 主要的抑制和三个主要的刺激神经递质系统将是 在这个项目中研究。

DESCRIPTION (Adapted from the Investigator's Abstract): This application will test the hypothesis that, in addition to its effects on neurotransmitter production and receptors, estrogen affects gonadotropin secretion in primates by regulating the synaptic connections between elements of the GnRH delivery system. The investigator proposes that by the time of the preovulatory gonadotropin surge, the ratio of the number of stimulatory and inhibitory synapses is higher on GnRH neurons than at any other time during the menstrual cycle. To test this hypothesis, the investigator will determine the synaptic connection and activity of GnRH neurons in the monkey brain during estrogen-regulated control of gonadotropins. During the project period, the investigator will study: 1) experimentally stimulated positive feedback induced by administered estradiol: 2) negative and positive feedback during the normal ovarian cycle; 3) feedback in normal males; 4) effects of ovariectomy with or without hormone replacement; and 5) naturally occurring menopause. Three major inhibitory and three major stimulator neurotransmitter systems will be studied in this project.