NOVEL COST EFFECTIVE ECG DETERMINATION OF FETAL ACIDOSIS

新颖、经济有效的心电图测定胎儿酸中毒

• 批准号: 2797107
• 负责人: Thomas H Frank
• 金额: $ 29.14万
• 依托单位: PERINATRONICS MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-08 至 2000-09-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2797107
• 关键词: acidosis; biomedical equipment development; clinical biomedical equipment; data collection methodology /evaluation; diagnosis quality /standard; electrocardiographic monitor; embryo /fetus monitoring; female; health care cost /financing; human pregnant subject; statistics /biometry

We propose to implement prototype instrumentation which will provide a novel means to acquire, process and present diagnostic quality fetal ECG waveforms and to utilize that instrumentation in a clinical study to assess fetal acidosis. This new technology would also help to prevent unnecessary Cesarean sections thus resulting in significant savings and reduction in the numbers and duration of hospital stays. Present methods of electronic fetal monitoring provide heart rate only. In preliminary studies we successfully employed an improved ECG lead arrangement and developed signal processing techniques to greatly enhance the weak fetal ECG signal complexes. We demonstrated the. feasibility to clinically acquire, process and present the fetal ECG T/QRS amplitude ratio which is associated with fetal acidosis. We extensively tested techniques to obtain fetal T/QRS ratio information in which we successfully employed a minimally invasive fetal ECG lead arrangement to achieve this. In a logical extension to this research, we propose to implement this study at several clinical centers. Our signal processing methods employ a new fetal ECG lead configuration, signal extraction techniques, and a novel means to selectively discriminate high quality fetal signals that accurately and precisely provide the fetal ECG waveform. Utilization of this instrumentation in a fetal ECG data collection project aimed at demonstrating the correlation of the fetal ECG T/QRS amplitude ratio with fetal blood pH, should provide a simple, cost effective, continuous, and accurate means to identify fetal acidosis.

我们建议实施原型仪器，这将提供一个 获取、处理和呈现诊断质量胎儿ECG的新方法 波形，并在临床研究中使用该仪器， 评估胎儿酸中毒。 这项新技术还将有助于防止 不必要的剖腹产手术，从而节省大量资金， 减少住院人数和住院时间。本方法 电子胎儿监护仪只提供心率。初步 研究我们成功地采用了改进的心电图导线排列， 开发了信号处理技术，大大提高了弱胎儿 ECG信号复合波。 我们展示了。临床可行性 采集、处理和显示胎儿ECG T/QRS振幅比， 与胎儿酸中毒有关 我们广泛测试了各种技术， 获得胎儿T/QRS比值信息，其中我们成功地采用了 微创胎儿心电图导联安排，以实现这一点。 中 逻辑延伸到这项研究，我们建议实施这项研究， 几个临床中心。 我们的信号处理方法采用了一种新的 胎儿心电图导联结构，信号提取技术，和一种新的 用于选择性地辨别高质量胎儿信号的装置， 准确、精确地提供胎儿心电波形。 利用 该仪器在胎儿心电图数据收集项目，旨在 证明胎儿ECG T/QRS振幅比与 胎儿血液pH值，应提供一个简单的，成本效益，连续， 准确的方法来识别胎儿酸中毒。