Reliable and Robust ECG Gating Signal for MR Imaging

用于 MR 成像的可靠且稳定的心电图门控信号

• 批准号: 6486301
• 负责人: Thomas H Frank
• 金额: $ 33.52万
• 依托单位: PERINATRONICS MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486301
• 关键词: artificial intelligence; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; bronchomotion; clinical research; electrocardiography; heart imaging /visualization /scanning; human subject; magnetic resonance imaging; optics; telemetry

The focus of this project is to develop and evaluate a noel and reliable system for ECG triggering during cardiac MR imaging. Understanding the mechanism of heart failure and cardiomyopathy using MRI requires reliable and robust ECG gating (or triggering). To provide effective ECG gating, the first specific aim of this Phase I project is to design and develop an ECG lead system and concomitant signal processing methodology to allow for improved ECG detection with the magnetic. Our preliminary data describing our optimal vector signal set approach , coupled with a dual derivative ECG detections scheme, appear to be effective in reliably detecting the ECG during MR imaging. An improved ECG trigger will provide cardiac MRI imaging without the artifacts of cardiac and respiratory motion. Our second specific aim is to design and develop a wireless (telemetry) infrared (IR) system for ECG trigger transmission to eliminate the need for either wiring or a fiber optic cable during MRI examinations. Additionally preliminary data demonstrates the capability of our IR telemetry system to transmit the ECG in laboratory tests. Our optimal telemetry system will also mitigate against many of the artifacts involved in the development of an effective MRI ECG trigger. During Phase I we will demonstrate the feasibility of our system by evaluating system performance in 20 human subjects undergoing cardiac MR imaging. We believe our approach should provide a reliable and robust ECG gated trigger with minimal delay from the onset of the R-wave. Such a trigger would minimize blurring artifacts from cardiac and respiratory motion and improve MR tagging studies. Should our phase I project be successful, we would develop a real-time implementation of the entire system in an expanded Phase II biomedical engineering and extended clinical study. A successful Phase I and II project would likely receive commercial backing from a major MRI instrument manufacturer. PROPOSED COMMERCIAL APPLICATIONS: Potential Commercial applications: Cardiac magnetic resonance imaging (MRI) is one of the most promising areas of MRI technology. There is a large potential commercial opportunity to develop a reliable and effective method to provide a real-time ECG gating and an infrared (IR) ECG telemetry link.

本项目的重点是开发和评估一种诺埃尔和可靠的系统，用于心脏MR成像过程中的ECG触发。使用MRI了解心力衰竭和心肌病的机制需要可靠和强大的ECG门控（或触发）。为了提供有效的ECG门控，该I期项目的第一个具体目标是设计和开发ECG导联系统和伴随的信号处理方法，以改进磁ECG检测。我们的初步数据描述了我们的最佳矢量信号集的方法，再加上一个双导数心电图检测方案，似乎是有效的，在MR成像过程中可靠地检测心电图。改进的ECG触发将提供心脏MRI成像，而没有心脏和呼吸运动的伪影。我们的第二个具体目标是设计和开发一种无线（遥测）红外（IR）系统，用于ECG触发传输，以消除在MRI检查期间对布线或光纤电缆的需要。此外，初步数据表明，我们的红外遥测系统的能力，在实验室测试中传输心电图。我们的最佳遥测系统还将减轻有效MRI ECG触发器开发中涉及的许多伪影。在第一阶段，我们将证明我们的系统的可行性，通过评估系统的性能在20个人类受试者进行心脏MR成像。我们相信，我们的方法应该提供一个可靠和强大的心电门控触发与R波的开始最小的延迟。这样的触发将最小化来自心脏和呼吸运动的模糊伪影，并改善MR标记研究。如果我们的第一阶段项目成功，我们将在扩展的第二阶段生物医学工程和扩展的临床研究中开发整个系统的实时实施。一个成功的I期和II期项目可能会得到一家主要MRI仪器制造商的商业支持。拟议的商业应用：潜在的商业应用：心脏磁共振成像（MRI）是MRI技术最有前途的领域之一。开发一种可靠有效的方法来提供实时ECG门控和红外（IR）ECG遥测链路具有很大的潜在商业机会。